Evidence map›Paper›PMID 34368224›Full record

ArticleFrontiers in molecular biosciences2021

Generating Chromosome Geometries in a Minimal Cell From Cryo-Electron Tomograms and Chromosome Conformation Capture Maps.

Benjamin R Gilbert, Zane R Thornburg, Vinson Lam, Fatema-Zahra M Rashid, John I Glass, Elizabeth Villa, Remus T Dame, Zaida Luthey-Schulten

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes.Protein science : a publication of the Protein Society · 2026
    Article
  2. Article
  3. Article
  4. Visualizing Cell Structures with Minecraft.Biophysicist (Rockville, Md.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Replicating Chromosomes in Whole-Cell Models of Bacteria.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. Integrative modeling of JCVI-Syn3A nucleoids with a modular approach.Current research in structural biology · 2024
    Article
  11. Article
  12. Review
  13. Investigation of Genome Biology by Synthetic Genome Engineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Article
  16. Dynamics of chromosome organization in a minimal bacterial cell.Frontiers in cell and developmental biology · 2023
    Article
  17. Integrative illustration of a JCVI-syn3A minimal cell.Journal of integrative bioinformatics · 2022
    Article
  18. Building Structural Models of a Whole Mycoplasma Cell.Journal of molecular biology · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Benjamin R GilbertDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Zane R ThornburgDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Vinson LamDivision of Biological Sciences, University of California San Diego, San Diego, CA, United States.
Fatema-Zahra M RashidLeiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
John I GlassSynthetic Biology Group, J. Craig Venter Institute, La Jolla, CA, United States.
Elizabeth VillaDivision of Biological Sciences, University of California San Diego, San Diego, CA, United States.
Remus T DameLeiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Zaida Luthey-SchultenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
University of Illinois Urbana-Champaign · USLeiden University · NLUniversity of California, San Diego · USJ. Craig Venter Institute · US

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Undergraduate Summer Research Experience: Molecular and cellular mechanisms of circadian timekeeping in a prokaryote modelR35GM118290 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDEN, SUSAN S · 2016 to 2025
$6.7M
Opening Windows into the Cell: Revealing the Molecular Architecture of the Nuclear PeripheryDP2GM123494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VILLA, ELIZABETH · 2016 to 2019
$2.5M
NIGMS NIH HHS DP2 GM123494NIGMS NIH HHS R35 GM118290NIGMS NIH HHS T32 GM007240
6 · The paper itself

Abstract

JCVI-syn3A is a genetically minimal bacterial cell, consisting of 493 genes and only a single 543 kbp circular chromosome. Syn3A's genome and physical size are approximately one-tenth those of the model bacterial organism

Indexed as

bacterial minimal cellchromosome conformation capture (3C) mapschromosome modelingcomputational modelingcryo-electron tomographyJCVI-syn3Aribosome distributionwhole-cell models

Identifiers

PMID34368224
PMCPMC8339304
OpenAlexW3185854339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.