Evidence map›Paper›PMID 34368198›Full record

ArticleFrontiers in medicine2021

Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy.

Željka Večerić-Haler, Nika Kojc, Matjaž Sever, Samo Zver, Urban Švajger, Primož Poženel, Katrina Hartman, Tereza Urdih, Gregor Mlinšek, Manca Oblak and 5 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. The Landscape of Advanced Therapy Medicinal Products in Slovenian Transfusion Medicine: A Review of Past and Future Outlook.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Željka Večerić-HalerDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Nika KojcInstitute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Matjaž SeverFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Samo ZverFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Urban ŠvajgerDivision for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia.
Primož PoženelDivision for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia.
Katrina HartmanDivision for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia.
Tereza UrdihDepartment of Haematology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Gregor MlinšekDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Manca OblakDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Andreja Aleš RiglerDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Alojz IhanInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Jadranka Buturović PonikvarDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Philip P HalloranDivision of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada.
Miha ArnolDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.

Indexed as

autologous stem cellcapillary leak syndromekidney graftkidney graft failurekidney graft rejectionkidney transplantmesenchymal stem cellstem cell transplant

Identifiers

PMID34368198
PMCPMC8334176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.