Evidence map›Paper›PMID 34368160›Full record

ReviewFrontiers in cell and developmental biology2021

A Comprehensive Overview of circRNAs: Emerging Biomarkers and Potential Therapeutics in Gynecological Cancers.

Yalan Ma, Lianwen Zheng, Yiyin Gao, Wenying Zhang, Qiang Zhang, Ying Xu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  10. Article
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  13. Emerging Roles of ncRNAs Regulating PKM2 in Cancer Progression.Current pharmaceutical biotechnology · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Recent Progress of CircRNAs in Hematological Malignancies.International journal of medical sciences · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yalan MaDepartment of Obstetrics and Gynecology, Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Lianwen ZhengDepartment of Obstetrics and Gynecology, Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Yiyin GaoDepartment of Obstetrics and Gynecology, Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Wenying ZhangDepartment of Obstetrics and Gynecology, Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Qiang ZhangDepartment of Obstetrics and Gynecology, Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Ying XuDepartment of Obstetrics and Gynecology, Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Second Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) is a highly conserved, stable and abundant non-coding RNA (ncRNA). Also, some circRNAs play an essential part in the progression of human cancers. CircRNA is different from traditional linear RNA. CircRNA has a closed circular structure, so it is resistant to exonuclease-mediated degradation and is more stable than linear RNA. Numerous studies have found that many circRNAs can act as a microRNA (miRNA) sponge, interact with RNA-binding proteins, regulate gene transcription, affect alternative splicing and be translated into proteins. Recently, some studies have also indicated that circRNA participates in the progression of gynecological cancers. In addition, circRNA can act as a promising biomarker for the diagnosis of gynecological tumors. Additionally, they can also play a key role in the prognosis of gynecological tumors. Furthermore, to our delight, circRNA may be a potential therapeutic target in gynecological cancers and widely used in clinical practice. This article reviews the functions and related molecular mechanisms of circRNAs in gynecological tumors, and discusses their potential as biomarkers for diagnostic and prognostic and therapeutic targets for gynecological cancers.

Indexed as

biomarkerscircular RNAexpressiongynecological cancerstherapeutics

Identifiers

PMID34368160
PMCPMC8335568
OpenAlexW3186313196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.