ReviewFrontiers in cell and developmental biology2021
The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models.
Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Disrupting fzd9b in Zebrafish Recapitulates Stress- and Anxiety-Like Behaviours Relevant to Williams Syndrome.Molecular neurobiology · 2026Article
- Synaptic Mitochondrial Respiration Differs Between the Prefrontal Cortex and Hippocampus in C57Bl/6NTac Mice.Molecular neurobiology · 2026Article
- Temperature and photoperiod stress in zebrafish larvae: impacts on development, gene regulation and PGC migration.Fish physiology and biochemistry · 2025Article
- Early-Life Heat Stress Impairs Cognition and Alters Its Covariation With Behaviour in Zebrafish.Ecology and evolution · 2025Article
- Parental social environment has transgenerational effects on zebrafish (Danio rerio) growth.Scientific reports · 2025Article
- The number of conspecific alarm substance donors notably influences the behavioural responses of zebrafish subjected to a traumatic stress procedure.Fish physiology and biochemistry · 2025Article
- Behavioral, metabolic, and biochemical alterations caused by an acute stress event in a zebrafish larvae model.Fish physiology and biochemistry · 2025Article
- Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.Military Medical Research · 2024Review
- Early-life challenge enhances cortisol regulation in zebrafish larvae.Biology open · 2024Article
- Cortisol dynamics and GR-dependent feedback regulation in zebrafish larvae exposed to repeated stress.Biology open · 2024Article
- Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish.Communications biology · 2024Article
- Article
- Cortisol Quantification for Assessing Stress-Induced Changes in Zebrafish Larvae.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Chronic early life stress alters the neuroimmune profile and functioning of the developing zebrafish gut.Brain, behavior, & immunity - health · 2023Article
- Leveraging big data to uncover the eco-evolutionary factors shaping behavioural development.Proceedings. Biological sciences · 2023Review
- Current State of Modeling Human Psychiatric Disorders Using Zebrafish.International journal of molecular sciences · 2023Review
- Altered glucocorticoid reactivity and behavioral phenotype in rx3-/- larval zebrafish.Frontiers in endocrinology · 2023Article
- Maternal Chronic Ethanol Exposure Decreases Stress Responses in Zebrafish Offspring.Biomolecules · 2022Article
- Transcriptome and Proteome Analyses Reveal Stage-Specific DNA Damage Response in Embryos of Sturgeon (International journal of molecular sciences · 2022Article
- Ultrastructural Analysis of a Forming Embryonic Embodiment in the Adult Zebrafish Optic Tectum Surviving in Organotypic Culture.NeuroSci · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early life period represents a window of increased vulnerability to stress, during which exposure can lead to long-lasting effects on brain structure and function. This stress-induced developmental programming may contribute to the behavioural changes observed in mental illness. In recent decades, rodent studies have significantly advanced our understanding of how early life stress (ELS) affects brain development and behaviour. These studies reveal that ELS has long-term consequences on the brain such as impairment of adult hippocampal neurogenesis, altering learning and memory. Despite such advances, several key questions remain inadequately answered, including a comprehensive overview of brain regions and molecular pathways that are altered by ELS and how ELS-induced molecular changes ultimately lead to behavioural changes in adulthood. The zebrafish represents a novel ELS model, with the potential to contribute to answering some of these questions. The zebrafish offers some important advantages such as the ability to non-invasively modulate stress hormone levels in a whole animal and to visualise whole brain activity in freely behaving animals. This review discusses the current status of the zebrafish ELS field and its potential as a new ELS model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.