Evidence map›Paper›PMID 34368109›Full record

ReviewFrontiers in bioengineering and biotechnology2021

Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy.

Rongwei Cui, Qiang Wu, Jing Wang, Xiaoming Zheng, Rongying Ou, Yunsheng Xu, Shuxin Qu, Danyang Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Rongwei CuiResearch Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Qiang WuResearch Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jing WangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Xiaoming ZhengResearch Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Rongying OuDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yunsheng XuDepartment of Dermatovenereology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Shuxin QuKey Lab of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, China.
Danyang LiResearch Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Sun Yat-sen University · CNThe Seventh Affiliated Hospital of Sun Yat-sen University · CNNorthwestern Polytechnical University · CNSouthwest Jiaotong University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.

Indexed as

cancer immunotherapyenvironmental regulatory substancehydrogelsimmune cellsimmunomodualtorssmart delivery

Identifiers

PMID34368109
PMCPMC8334721
OpenAlexW3184375351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.