ReviewFrontiers in cellular and infection microbiology2021
Recurrent Urinary Tract Infections: Unraveling the Complicated Environment of Uncomplicated rUTIs.
Review in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial.BMC urology · 2025Trial
- Oral antibiotic exposure and urinary tract infection risk in adults: a self-controlled case series study.EClinicalMedicine · 2026Article
- Differential antimicrobial responses in polymicrobial triple-species biofilms associated with persistent urinary tract infections.Scientific reports · 2026Article
- High-throughput methods leveraging robotics and computer vision for the development of therapeutic phage cocktails.Nature communications · 2026Article
- More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026Review
- Quantitative microbial risk assessment of extended-spectrum β-lactamase-producingScience in One Health · 2026Article
- Beyond the bladder: Escherichia coli UTIs drive systemic inflammation and RANKL-mediated bone resorption.Irish journal of medical science · 2025Article
- Antioxidant Status in Children with Neurogenic Bladder.Children (Basel, Switzerland) · 2025Article
- A Rare Case of Antenatal Bilateral Multicystic Dysplastic Kidney Disease: An Unusual Presentation in a Neonate.Clinical case reports · 2025Article
- An Overview of the Association of the Urinary Tract Microbiome with Various Diseases and Implications for Therapeutics.Mini reviews in medicinal chemistry · 2025Review
- Effects of a supplement associatingInvestigative and clinical urology · 2025Article
- Gut Microbiome Implication and Modulation in the Management of Recurrent Urinary Tract Infection.Pathogens (Basel, Switzerland) · 2024Review
- The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics.Open forum infectious diseases · 2024Review
- The Role of Metabolomics and Microbiology in Urinary Tract Infection.International journal of molecular sciences · 2024Review
- Urinary tract infection: is it time for a new approach considering a gender perspective and new microbial advances?Frontiers in urology · 2024Review
- Correlation of procalcitonin and c-reactive protein levels with pathogen distribution and infection localization in urinary tract infections.Scientific reports · 2023Article
- Microbiota Profiling on Veterinary Faculty Restroom Surfaces and Source Tracking.Microorganisms · 2023Article
- Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Urinary Tract Infection and Microbiome.Diagnostics (Basel, Switzerland) · 2023Review
- Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder.Urology case reports · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infections (UTIs) are frequent in humans, affecting the upper and lower urinary tract. Present diagnosis relies on the positive culture of uropathogenic bacteria from urine and clinical markers of inflammation of the urinary tract. The bladder is constantly challenged by adverse environmental stimuli which influence urinary tract physiology, contributing to a dysbiotic environment. Simultaneously, pathogens are primed by environmental stressors such as antibiotics, favoring recurrent UTIs (rUTIs), resulting in chronic illness. Due to different confounders for UTI onset, a greater understanding of the fundamental environmental mechanisms and microbial ecology of the human urinary tract is required. Such advancements could promote the tandem translation of bench and computational studies for precision treatments and clinical management of UTIs. Therefore, there is an urgent need to understand the ecological interactions of the human urogenital microbial communities which precede rUTIs. This review aims to outline the mechanistic aspects of rUTI ecology underlying dysbiosis between both the human microbiome and host physiology which predisposes humans to rUTIs. By assessing the applications of next generation and systems level methods, we also recommend novel approaches to elucidate the systemic consequences of rUTIs which requires an integrated approach for successful treatment. To this end, we will provide an outlook towards the so-called 'uncomplicated environment of UTIs', a holistic and systems view that applies ecological principles to define patient-specific UTIs. This perspective illustrates the need to withdraw from traditional reductionist perspectives in infection biology and instead, a move towards a systems-view revolving around patient-specific pathophysiology during UTIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.