Evidence map›Paper›PMID 34367772›Full record

ArticleCureus2021

Acute Limb Ischemia Complicated by Heparin-Induced Thrombocytopenia in an Asymptomatic COVID-19 Patient.

Nabeel A Siddiqui, Enkhmaa Luvsannyam, Molly S Jain, Muhammad Abbas, Arathi Jayaraman, Redjon Zhuleku, Nayaab Ullah, Alma Corona, Mohammad T Hussain

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Nabeel A SiddiquiResearch, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Enkhmaa LuvsannyamResearch, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Molly S JainMedicine, Saint James School of Medicine, Park Ridge, USA.
Muhammad AbbasMedicine, Avalon University School of Medicine, Willemstad, CUW.
Arathi JayaramanMedicine, Xavier University School of Medicine, Oranjestad, ABW.
Redjon ZhulekuMedicine, Medical University of Lublin, Lublin, POL.
Nayaab UllahHematology and Oncology, Windsor University School of Medicine, Cayon, KNA.
Alma CoronaHematology and Oncology, Advanced Cancer Care Center, North Aurora, USA.
Mohammad T HussainHematology and Oncology, Advanced Cancer Care Center, North Aurora, USA.
Palmetto Hematology Oncology · USCalifornia Institute of Behavioral Neurosciences and Psychology (United States) · USAvalon University School of Medicine · CWMedical University of Lublin · PLUniversity of Colorado Denver · USXavier University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute limb ischemia (ALI) is the sudden decrease in limb perfusion caused by embolism secondary to many blood stasis conditions. Treatment commences with intravenous (IV) unfractionated heparin infusion. Individuals can have an immune-mediated reaction to heparin products which results in heparin-induced thrombocytopenia (HIT). Coronavirus disease 2019 (COVID-19) has added to the difficulty of treating patients with ALI due to increasing the likelihood of HIT via the virus's ability to manipulate the coagulation parameters. We present a case of ALI complicated by HIT in a 49-year-old male with a confirmed asymptomatic COVID-19. The patient initially presented with progressive pain, coldness, and tingling in the right foot. He was treated with a tissue plasminogen activator (TPA) and a heparin drip. The occlusion persisted despite medical intervention leading to right below-knee amputation. The patient returned to the emergency department (ED) 13 days later with massive intracranial hemorrhage and subsequently expired. This case study demonstrates the significance of COVID-19 diagnostic testing due to the possibility of developing blood clots and potential complications, including HIT.

Indexed as

acute limb ischemiaanticoagulationcoronaviruscovid-19heparin-induced thrombocytopeniarutherford classifications

Identifiers

PMID34367772
PMCPMC8330877
OpenAlexW3179042197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.