Evidence map›Paper›PMID 34367644›Full record

ArticleSAGE open medical case reports2021

Detection of dengue virus serotype 1 in central nervous system of a child in Bandung, West Java: A case report.

Dewi Hawani Alisjahbana, Syndi Nurmawati, Dzulfikar Dl Hakim, Mia Milanti, Yora Permata Dewi, Edison Johar, Khin Saw Aye Myint, Jeremy P Lederman, Ann M Powers, Bachti Alisjahbana and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in SAGE open medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Dewi Hawani AlisjahbanaDepartment of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Syndi NurmawatiResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
Dzulfikar Dl HakimDepartment of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Mia MilantiDepartment of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Yora Permata DewiEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.ORCID https://orcid.org/0000-0001-5279-8892
Edison JoharEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Khin Saw Aye MyintEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-2087-7331
Jeremy P LedermanCenters for Disease Control and Prevention, Fort Collins, CO, USA.
Ann M PowersCenters for Disease Control and Prevention, Fort Collins, CO, USA.
Bachti AlisjahbanaResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
Ungke AntonjayaEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Dr. Hasan Sadikin General Hospital · IDEijkman Institute for Molecular Biology · IDCenters for Disease Control and Prevention · USPadjadjaran University · ID

Funding

NCEZID CDC HHS U01 CK000577NCEZID CDC HHS U18 CK000443
6 · The paper itself

Abstract

Central nervous system involvement of dengue virus is increasingly reported from endemic areas. This study describes the clinical characteristics and laboratory features of a pediatric patient enrolled in a central nervous system illness study conducted in 2017-2018 to identify viral and bacterial etiologies in Indonesian children. Dengue diagnostics including molecular and serological testing were performed on an encephalitis patient who presented with both classical dengue and neurological clinical symptoms. Dengue virus serotype 1 RNA was detected in both cerebrospinal fluid and serum by serotype-specific reverse transcription polymerase chain reaction, and the E gene was successfully sequenced. Anti-dengue virus immunoglobulin M was detected in both admission and discharge sera, whereas anti-dengue virus immunoglobulin G was identified only in the discharge serum. This study describes the central nervous system complications in a case with dengue virus infection in West Java, Indonesia, and highlights the potential for dengue virus serotype 1, a serotype rarely associated with neurotropism, to cause encephalitis.

Indexed as

central nervous systemDengueencephalitisIndonesiaserotype 1

Identifiers

PMID34367644
PMCPMC8312185
OpenAlexW3183210363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.