ReviewWorld journal of hepatology2021
Clinical algorithms for the prevention of variceal bleeding and rebleeding in patients with liver cirrhosis.
Review in World journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Graph Neural Networks for Realistic Bleeding Prediction in Surgical Simulators.Journal of imaging informatics in medicine · 2026Article
- Variceal Upper Gastrointestinal Bleeding: A Retrospective Cohort of 98 Cases, Historical Comparison, and Updated Management Algorithm.Life (Basel, Switzerland) · 2025Article
- Application of artificial intelligence in portal hypertension and esophagogastric varices.World journal of gastroenterology · 2025Review
- Efficacy and safety of transjugular intrahepatic portosystemic shunt versus endoscopic variceal ligation for variceal rebleeding: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- Development and validation of a machine learning model to predict hemostatic intervention in patients with acute upper gastrointestinal bleeding.BMC medical informatics and decision making · 2025Article
- Article
- A Rare Case of Portal Hypertension and Ascites Following Intrauterine Fetal Death: A Case Report.Cureus · 2024Article
- The Prediction and Treatment of Bleeding Esophageal Varices in the Artificial Intelligence Era: A Review.Cureus · 2024Review
- The prognostic evaluation of ALBI score in endoscopic treatment of esophagogastric varices hemorrhage in liver cirrhosis.Scientific reports · 2024Article
- Article
- Prospects for treatment of esophageal varices considering the safety of endoscopic band ligation.Hepatology international · 2023Article
- Review
- Evaluation of Low-Molecular-Weight Heparin for Treatment of Portal Vein Thrombosis in Liver Cirrhosis Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Analysis of Complications and Risk Factors Other than Bleeding before and after Endoscopic Treatment of Esophagogastric Variceal Bleeding in Patients with Liver Cirrhosis.Canadian journal of gastroenterology & hepatology · 2023Article
- Acute Upper Gastrointestinal Bleeding: Less Severe Bleeding in More Frail and Older Patients, Comparison Between Two Time Periods Fifteen Years Apart.Gastroenterology research · 2022Article
- Recurrent graft failure secondary to portal vein steal syndrome: a case report with an unusual indication for a third liver transplant.BMC surgery · 2022Article
- Elective Transjugular Intrahepatic Portosystemic Shunt Using Viatorr Stent-Grafts: A Single-Center Experience from China.Journal of the Belgian Society of Radiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Portal hypertension (PH), a common complication of liver cirrhosis, results in development of esophageal varices. When esophageal varices rupture, they cause significant upper gastrointestinal bleeding with mortality rates up to 20% despite state-of-the-art treatment. Thus, prophylactic measures are of utmost importance to improve outcomes of patients with PH. Several high-quality studies have demonstrated that non-selective beta blockers (NSBBs) or endoscopic band ligation (EBL) are effective for primary prophylaxis of variceal bleeding. In secondary prophylaxis, a combination of NSBB + EBL should be routinely used. Once esophageal varices develop and variceal bleeding occurs, standardized treatment algorithms should be followed to minimize bleeding-associated mortality. Special attention should be paid to avoidance of overtransfusion, early initiation of vasoconstrictive therapy, prophylactic antibiotics and early endoscopic therapy. Pre-emptive transjugular intrahepatic portosystemic shunt should be used in all Child C10-C13 patients experiencing variceal bleeding, and potentially in Child B patients with active bleeding at endoscopy. The use of carvedilol, safety of NSBBs in advanced cirrhosis (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.