Evidence map›Paper›PMID 34367379›Full record

ArticleDisease markers2021

Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients.

Jean Paul Nshizirungu, Sanae Bennis, Ihsane Mellouki, Mohammed Sekal, Dafr-Allah Benajah, Nada Lahmidani, Hicham El Bouhaddouti, Karim Ibn Majdoub, Sidi Adil Ibrahimi, Sónia Pires Celeiro and 6 more

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Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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  18. Research advances in the molecular classification of gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jean Paul NshizirunguBiomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.ORCID https://orcid.org/0000-0003-0986-4588
Sanae BennisBiomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.ORCID https://orcid.org/0000-0001-6405-8322
Ihsane MelloukiDepartment of Gastroenterology, Faculty of Medicine and Pharmacy, Abdelmalek Essaadi University, Tangier, Morocco.
Mohammed SekalLaboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Dafr-Allah BenajahDepartment of Gastroenterology, Hassan II University Hospital, Fez, Morocco.
Nada LahmidaniDepartment of Gastroenterology, Hassan II University Hospital, Fez, Morocco.
Hicham El BouhaddoutiDepartment of Visceral Surgery, Hassan II University Hospital, Fez, Morocco.
Karim Ibn MajdoubDepartment of Visceral Surgery, Hassan II University Hospital, Fez, Morocco.
Sidi Adil IbrahimiDepartment of Gastroenterology, Hassan II University Hospital, Fez, Morocco.
Sónia Pires CeleiroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Marta Viana-PereiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Fernanda Franco MunariMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Guilherme Gomes RibeiroPathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Vinicius DuvalPathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Iara SantanaPathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Rui Manuel ReisLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID https://orcid.org/0000-0002-9639-7940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Cancer Genome Atlas (TCGA) project and Asian Cancer Research Group (ACRG) recently categorized gastric cancer into molecular subtypes. Nevertheless, these classification systems require high cost and sophisticated molecular technologies, preventing their widespread use in the clinic. This study is aimed to generating molecular subtypes of gastric cancer using techniques available in routine diagnostic practice in a series of Moroccan gastric cancer patients. In addition, we assessed the associations between molecular subtypes, clinicopathological features, and prognosis.

methodsNinety-seven gastric cancer cases were classified according to TCGA, ACRG, and integrated classifications using a panel of four molecular markers (EBV, MSI, E-cadherin, and p53). HER2 status and PD-L1 expression were also evaluated. These markers were analyzed using immunohistochemistry (E-cadherin, p53, HER2, and PD-L1), in situ hybridization (EBV and HER2 equivocal cases), and multiplex PCR (MSI).

resultsOur results showed that the subtypes presented distinct clinicopathological features and prognosis. EBV-positive gastric cancers were found exclusively in male patients. The GS (TCGA classification), MSS/EMT (ACRG classification), and E-cadherin aberrant subtype (integrated classification) presented the Lauren diffuse histology enrichment and tended to be diagnosed at a younger age. The MSI subtype was associated with a better overall survival across all classifications (TCGA, ACRG, and integrated classification). The worst prognosis was observed in the EBV subtype (TCGA and integrated classification) and MSS/EMT subtype (ACRG classification).

Indexed as

AdultAgedAged, 80 and overAge FactorsBiomarkers, TumorDatabases, GeneticDiagnostic Tests, RoutineEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansMaleMiddle AgedMoroccoPrognosisSex CharacteristicsBiomarkers, Tumor

Identifiers

PMID34367379
PMCPMC8342151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.