Evidence map›Paper›PMID 34367377›Full record

ArticleDisease markers2021

Interleukin-18: A Novel Participant in the Occurrence, Development, and Drug Therapy of Obliterative Bronchiolitis Postlung Transplantation.

Ping Shu, Wei Zhang, Yanfei Zhang, Yanfeng Zhao, Yuping Li, Xiaoqing Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ping ShuDepartment of Pharmacy, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-6094-1801
Wei ZhangDepartment of Pharmacy, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-6909-9649
Yanfei ZhangDepartment of Pharmacy, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-2641-6966
Yanfeng ZhaoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-5037-8077
Yuping LiDepartment of Pharmacy, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-5209-4131
Xiaoqing ZhangDepartment of Pharmacy, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-3652-723X
Tongji University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObliterative bronchiolitis (OB) was a main cause of deterioration of long-term prognosis in lung transplant recipients after the first posttransplant year. Proinflammatory cytokine interleukin-18 (IL-18) strengthened both the natural immunity and acquired immunity and played an important role in organ transplantation. The roles of IL-18 in the occurrence, development, and drug treatment of OB remained unclear.

methodsSmall interfering RNA (siRNA) against mouse IL-18 (siRNA-IL-18) was used to silence IL-18 expression. Mouse heterotopic tracheal transplantation model was used to simulate OB. Recipient mice were divided into 5 groups (

resultsThe luminal obliteration rates of IL-18 of the siRNA-IL-18 group were significantly lower than those of the negative control group (

conclusionsIL-18 could be a novel molecular involved in the occurrence, development, and drug treatment of OB.

Indexed as

AnimalsAzithromycinBasiginBronchiolitis ObliteransDisease Models, AnimalHumansInterferon-gammaInterleukin-18Lung TransplantationMaleMatrix Metalloproteinase 8Matrix Metalloproteinase 9MiceRNA, Small InterferingTacrolimusTransplantation, HomologousAzithromycinBasiginBsg protein, mouseIFNG protein, mouseInterferon-gammaInterleukin-18Matrix Metalloproteinase 8Matrix Metalloproteinase 9MMP8 protein, mouseMmp9 protein, mouseRNA, Small InterferingTacrolimus

Identifiers

PMID34367377
PMCPMC8337162
OpenAlexW3211535979

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.