ArticleCognitive neurodynamics2021
A dynamical model for the basal ganglia-thalamo-cortical oscillatory activity and its implications in Parkinson's disease.
Article in Cognitive neurodynamics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Common and specific effects in brain oscillations and motor symptoms of tDCS and tACS in Parkinson's disease.Cell reports. Medicine · 2025Trial
- Modeling characteristics of neuronal firing in the thalamocortical network of connections in control and parkinsonian primates.Journal of computational neuroscience · 2025Article
- Abnormal activity in the brainstem affects gait in a neuromusculoskeletal model.Journal of neuroengineering and rehabilitation · 2025Article
- Age-related changes in neural oscillations vary as a function of brain region and frequency band.Frontiers in aging neuroscience · 2025Article
- Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states.Cognitive neurodynamics · 2024Article
- Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington's disease and treatment.Cognitive neurodynamics · 2024Article
- The neuronal and synaptic dynamics underlying post-inhibitory rebound burst related to major depressive disorder in the lateral habenula neuron model.Cognitive neurodynamics · 2024Article
- Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model.Cognitive neurodynamics · 2024Article
- The onset of motor learning impairments in Parkinson's disease: a computational investigation.Brain informatics · 2024Article
- 2D dynamic analysis of the disturbances in the calcium neuronal model and its implications in neurodegenerative disease.Cognitive neurodynamics · 2023Article
- Closed-loop modulation of model parkinsonian beta oscillations based on CAR-fuzzy control algorithm.Cognitive neurodynamics · 2023Article
- A model description of beta oscillations in the external globus pallidus.Cognitive neurodynamics · 2023Article
- Infectious Microorganisms Seen as Etiologic Agents in Parkinson's Disease.Life (Basel, Switzerland) · 2023Review
- GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders.Pharmacological reports : PR · 2022Review
- Excitability and Threshold Mechanism for Enhanced Neuronal Response Induced by Inhibition Preceding Excitation.Neural plasticity · 2021Article
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Authors and funding
3 authors.
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Abstract
We propose to investigate brain electrophysiological alterations associated with Parkinson's disease through a novel adaptive dynamical model of the network of the basal ganglia, the cortex and the thalamus. The model uniquely unifies the influence of dopamine in the regulation of the activity of all basal ganglia nuclei, the self-organised neuronal interdependent activity of basal ganglia-thalamo-cortical circuits and the generation of subcortical background oscillations. Variations in the amount of dopamine produced in the neurons of the substantia nigra pars compacta are key both in the onset of Parkinson's disease and in the basal ganglia action selection. We model these dopamine-induced relationships, and Parkinsonian states are interpreted as spontaneous emergent behaviours associated with different rhythms of oscillatory activity patterns of the basal ganglia-thalamo-cortical network. These results are significant because: (1) the neural populations are built upon single-neuron models that have been robustly designed to have eletrophysiologically-realistic responses, and (2) our model distinctively links changes in the oscillatory activity in subcortical structures, dopamine levels in the basal ganglia and pathological synchronisation neuronal patterns compatible with Parkinsonian states, this still remains an open problem and is crucial to better understand the progression of the disease.
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