ArticleNature photonics2020
Harmonic optical tomography of nonlinear structures.
Article in Nature photonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Label-free correlative morpho-chemical tomography of 3D kidney mesangial cells.Journal of biomedical optics · 2026Article
- Enhanced magnetic second-harmonic generation in an ultra-compact plasmonic nanocavity.Light, science & applications · 2025Article
- Super-resolved coherent anti-Stokes Raman scattering microscopy by coherent image scanning.Nature communications · 2024Article
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Statistical estimation theory detection limits for label-free imaging.Journal of biomedical optics · 2024Article
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part II.Journal of biomedical optics · 2024Review
- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Simultaneous 3D Construction and Imaging of Plant Cells Using Plasmonic Nanoprobe-Assisted Multimodal Nonlinear Optical Microscopy.Nanomaterials (Basel, Switzerland) · 2023Article
- Bond-selective intensity diffraction tomography.Nature communications · 2022Article
- Cell Cycle Stage Classification Using Phase Imaging with Computational Specificity.ACS photonics · 2022Article
- Live-dead assay on unlabeled cells using phase imaging with computational specificity.Nature communications · 2022Article
- Synthetic aperture interference light (SAIL) microscopy for high-throughput label-free imaging.Applied physics letters · 2021Article
- Dehydration of plant cells shoves nuclei rotation allowing for 3D phase-contrast tomography.Light, science & applications · 2021Article
- Computational interference microscopy enabled by deep learning.APL photonics · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Second-harmonic generation microscopy is a valuable label-free modality for imaging non-centrosymmetric structures and has important biomedical applications from live-cell imaging to cancer diagnosis. Conventional second-harmonic generation microscopy measures intensity signals that originate from tightly focused laser beams, preventing researchers from solving the scattering inverse problem for second-order nonlinear materials. Here, we present harmonic optical tomography (HOT) as a novel modality for imaging microscopic, nonlinear and inhomogeneous objects. The HOT principle of operation relies on inter-ferometrically measuring the complex harmonic field and using a scattering inverse model to reconstruct the three-dimensional distribution of harmonophores. HOT enables strong axial sectioning via the momentum conservation of spatially and temporally broadband fields. We illustrate the HOT operation with experiments and reconstructions on a beta-barium borate crystal and various biological specimens. Although our results involve second-order nonlinear materials, we show that this approach applies to any coherent nonlinear process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.