Evidence map›Paper›PMID 34367285›Full record

ArticleJournal of oncology2021

Clinical Effect of Iodine-125 Seed Implantation in Patients with Primary Liver Cancer and Its Effect on Th1/Th2 Cells in Peripheral Blood.

Xiaoyan Chen, Fan Zhu, Bin Wang, Yu Zhou, Hao Xiong, Tao Fan, Wenjie Ke

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  8. Lentinan Combined with (125)I Brachytherapy for Recurrent Ovarian Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiaoyan ChenDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID https://orcid.org/0000-0002-1856-0626
Fan ZhuDepartment of Hepatobiliary Surgery, Ezhou Central Hospital, Ezhou 436099, China.
Bin WangDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Yu ZhouDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Hao XiongDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Tao FanDepartment of Outpatient, Chengdu Wuhou District Enxi Medical Cosmetology Hospital, Chengdu 610047, China.
Wenjie KeDepartment of Henia and Abdominal Wall Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong Univerity of Science and Technology, Wuhan 430030, China.ORCID https://orcid.org/0000-0002-3159-672X
Wuhan University · CNCentral Hospital of Wuhan · CNEzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the clinical effect of iodine-125 seed implantation combined with chemotherapy in patients with primary liver cancer and the effect on peripheral blood Th1/Th2 cells.

methodsA total of 136 patients with primary liver cancer from April 2017 to June 2018 were selected as subjects and randomly divided into the control group and observation group with 68 cases in each group. The control group was treated with chemotherapy, and the observation group was treated with iodine-125 seed implantation on the basis of the control group. After 3 months of treatment, the curative effect was investigated. Serum tumor markers, peripheral blood Th1/Th2 cells, and side effects and recurrence rate were compared between the two groups.

resultsThe levels of serum tumor markers in both groups at 3 months after treatment were lower than before treatment (

conclusionIodine-125 seed implantation combined with chemotherapy in patients with primary liver cancer can reduce the level of serum tumor markers, improve the level of peripheral blood Th1/Th2 cells, and reduce the recurrence rate of patients without increasing the incidence of side effects, which is worthy of promoting the application of iodine-125 seed implantation.

Identifiers

PMID34367285
PMCPMC8342174
OpenAlexW3183799911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.