Evidence map›Paper›PMID 34367254›Full record

ArticleFrontiers in genetics2021

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach.

Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu, Qing Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yangchun ZhangDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Ziqi LiuDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Qianmei HeDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Fei WuDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Yongmei XiaoDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Wen ChenDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Yuan JinDepartment of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Dianke YuDepartment of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Qing WangDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although it is recognized that cadmium (Cd) causes renal tubular dysfunction, the mechanism of Cd-induced nephrotoxicity is not yet fully understood. Mode of action (MOA) is a developing tool for chemical risk assessment. To establish the mechanistic MOA of Cd-induced renal tubular dysfunction, the Comparative Toxicogenomics Database (CTD) was used to obtain genomics data of Cd-induced nephrotoxicity, and Ingenuity

Indexed as

cadmiummode of actionpathway analysisrenal tubular dysfunctionweight of evidence

Identifiers

PMID34367254
PMCPMC8343180
OpenAlexW3183855231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.