ArticleFrontiers in genetics2021
Obesity, Type 2 Diabetes, and the Risk of Carpal Tunnel Syndrome: A Two-Sample Mendelian Randomization Study.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Examining the role of insulin-like growth factor 1 in the pathophysiology of carpal tunnel syndrome: a Mendelian randomization study.International journal of epidemiology · 2026Article
- Visual Attention and Strategic Sophistication in the Strategic Environment Effect: An Eye-Tracking Approach.Journal of eye movement research · 2026Article
- Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults.Clinical pharmacology and therapeutics · 2026Article
- Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome.International journal of molecular sciences · 2026Article
- Diagnostic Accuracy of Electrodiagnostic Comparative Latency Studies of Carpal Tunnel Syndrome: Single Test and Concordance Between Multiple Tests.Diagnostics (Basel, Switzerland) · 2025Article
- Body mass index and the risk of ulnar nerve entrapment in individuals without diabetes-a longitudinal cohort study from Sweden.International journal of obesity (2005) · 2025Article
- Carpal Tunnel Syndrome as an Early Underrecognized Feature of Rheumatoid Arthritis: A Population-Based Study of Carpal Tunnel Syndrome Occurrence Before and After Rheumatoid Arthritis Incidence.Arthritis care & research · 2025Article
- Unraveling the causality between carpal tunnel syndrome and trigger finger through genetic instrumental variables.European journal of medical research · 2025Article
- The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.Nature communications · 2025Article
- Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies.European journal of medical research · 2025Article
- Article
- The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.medRxiv : the preprint server for health sciences · 2025Article
- Obesity as a Risk Factor for Carpal Tunnel Syndrome Independent of Diabetes Mellitus: A Nationwide Study.Journal of hand surgery global online · 2025Article
- The Association Between Bariatric Surgery and Surgical Outcomes Following Open Carpal Tunnel Release.Cureus · 2025Article
- Smoking may be a risk factor for carpal tunnel syndrome: Insights from Mendelian randomization analysis.Tobacco induced diseases · 2025Article
- Risk factors, associations, and high-risk patient profiles for nocturnal pain in carpal tunnel syndrome: implications for patient care.Musculoskeletal surgery · 2024Article
- Prevalence and Predictors of Carpal Tunnel Syndrome Symptoms Among Teachers in Jazan: A Cross-Sectional Study.Cureus · 2024Article
- Causal associations of Insomnia and postpartum depression: a two-sample mendelian randomization study.Archives of gynecology and obstetrics · 2024Article
- Relationship of obesity indices with clinical severity and nerve conduction studies in females presenting with median nerve compression neuropathy at the wrist.Journal of family medicine and primary care · 2024Article
- Hyperglycaemia is a causal risk factor for upper limb pathologies.International journal of epidemiology · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some previous observational studies have reported an increased risk of carpal tunnel syndrome (CTS) in patients with obesity or type 2 diabetes (T2D), which was however, not observed in some other studies. In this study we performed a two-sample Mendelian randomization to assess the causal effect of obesity, T2D on the risk of CTS. Single nucleotide polymorphisms associated with the body mass index (BMI) and T2D were extracted from genome-wide association studies. Summary-level results of CTS were available through FinnGen repository. Univariable Mendelian randomization (MR) with inverse-variance-weighted method indicated a positive correlation of BMI with CTS risk [odds ratio (OR) 1.66, 95% confidence interval (CI), 1.39-1.97]. Genetically proxied T2D also significantly increased the risk of CTS [OR 1.17, 95% CI (1.07-1.29)]. The causal effect of BMI and T2D on CTS remained consistent after adjusting for each other with multivariable MR. Our mediation analysis indicated that 34.4% of BMI's effect of CTS was mediated by T2D. We also assessed the effects of several BMI and glycemic related traits on CTS. Waist circumference and arm fat-free mass were also causally associated with CTS. However, the associations disappeared after adjusting for the effect of BMI. Our findings indicate that obesity and T2D are independent risk factors of CTS.
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