Evidence map›Paper›PMID 34367159›Full record

ArticleFrontiers in immunology2021

IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming.

Emma de Jong, Jean-Francois Lauzon-Joset, Jonatan Leffler, Michael Serralha, Alexander N Larcombe, Claus T Christophersen, Patrick G Holt, Deborah H Strickland, Anthony Bosco

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Emma de JongTelethon Kids Institute, Perth, WA, Australia.
Jean-Francois Lauzon-JosetTelethon Kids Institute, Perth, WA, Australia.
Jonatan LefflerTelethon Kids Institute, Perth, WA, Australia.
Michael SerralhaTelethon Kids Institute, Perth, WA, Australia.
Alexander N LarcombeTelethon Kids Institute, Perth, WA, Australia.
Claus T ChristophersenWA Human Microbiome Collaboration Centre, School of Molecular and Life Sciences, Curtin University, Bentley, WA, Australia.
Patrick G HoltTelethon Kids Institute, Perth, WA, Australia.
Deborah H StricklandTelethon Kids Institute, Perth, WA, Australia.
Anthony BoscoTelethon Kids Institute, Perth, WA, Australia.
The Kids Research Institute Australia · AUEdith Cowan University · AUUniversité Laval · CAUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high (BN)

Indexed as

AllergensAnimalsAsthmaBacterial LysatesCardiovirus InfectionsCell ExtractsImmunophenotypingInterferon Regulatory Factor-7MaleRatsAllergensBacterial LysatesBroncho-VaxomCell ExtractsInterferon Regulatory Factor-7allergenasthma exacerbationimmunomodulationIRF7rhinovirussystems biology

Identifiers

PMID34367159
PMCPMC8339879
OpenAlexW3185556831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.