Evidence map›Paper›PMID 34367074›Full record

ReviewFrontiers in endocrinology2021

Newer Insights Into Fetal Growth and Body Composition.

Satoru Ikenoue, Yoshifumi Kasuga, Toyohide Endo, Mamoru Tanaka, Daigo Ochiai

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Fetal Body Composition and Organ Volume Trajectories in Association With Maternal Perceived Stress or Depressive Symptoms in the Fetal 3D Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  7. Observational
  8. Article
  9. Article
  10. Origins of obesity in the womb: Fetal adiposity and its determinants.The journal of obstetrics and gynaecology research · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Satoru IkenoueDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Yoshifumi KasugaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Toyohide EndoDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Mamoru TanakaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Daigo OchiaiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on epidemiological and experimental evidence, the origins of childhood obesity and early onset metabolic syndrome can be extended back to developmental processes during intrauterine life. It is necessary to actively investigate antecedent conditions that affect fetal growth by developing reliable measures to identify variations in fetal fat deposition and body composition. Recently, the resolution of ultrasonography has remarkably improved, which enables better tissue characterization and quantification of fetal fat accumulation. In addition, fetal fractional limb volume has been introduced as a novel measure to quantify fetal soft tissue volume, including fat mass and lean mass. Detecting extreme variations in fetal fat deposition may provide further insights into the origins of altered fetal body composition in pathophysiological conditions (i.e., fetal growth restriction or fetal macrosomia), which are predisposed to the metabolic syndrome in later life. Further studies are warranted to determine the maternal or placental factors that affect fetal fat deposition and body composition. Elucidating these factors may help develop clinical interventions for altered fetal growth and body composition, which could potentially lead to primary prevention of the future risk of metabolic dysfunction.

Indexed as

AdiposityBody CompositionFetal DevelopmentFemaleFetal Growth RetardationHumansPediatric ObesityPregnancyDOHaDfetal body compositionfetal growth restrictionfetal subcutaneous fatfetal ultrasoundfractional limb volumemacrosomiapredisposition

Identifiers

PMID34367074
PMCPMC8339915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.