Evidence map›Paper›PMID 34367060›Full record

ArticleFrontiers in endocrinology2021

Determining Diagnostic Criteria of Unexplained Recurrent Implantation Failure: A Retrospective Study of Two

Yingying Sun, Yile Zhang, Xueshan Ma, Weitong Jia, Yingchun Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  7. Treatment experience of patients with failedFrontiers in public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yingying SunCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yile ZhangCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xueshan MaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Weitong JiaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yingchun SuCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The definition of recurrent implantation failure (RIF) differs clinically, one of the most controversial diagnostic criteria is the number of failed treatment cycles. We tried to investigate whether the two implantation failure could be included in the diagnostic criteria of RIF. Methods: A retrospective analysis of the clinical data of patients (N=1518) aged under 40 years with two or more implantation failure, recruited from the Center for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University from January 2016 to June 2019. Results: After adjusting for confounding factors by using binary logistic regression, the results showed that partial general information and: distribution of associated factors were significant differences such as maternal age ( Conclusion: For patients with unexplained recurrent implantation failure, two implantation failure cannot be included in the diagnostic criteria of RIF. This study supports the generally accepted definition of three or more failed treatment cycles for RIF.

Indexed as

Embryo ImplantationAdultFemaleHumansLogistic ModelsPregnancyPregnancy OutcomeRecurrenceRetrospective StudiesTreatment Failuredefinitionembryos transfer cyclesfactoroutcomerecurrent implantation failure

Identifiers

PMID34367060
PMCPMC8339466
OpenAlexW3186615327

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.