ReviewFrontiers in psychiatry2021
The Different Facets of Heart Rate Variability in Obstructive Sleep Apnea.
Review in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Electrocardiogram heart rate variability for machine learning diagnosis of obstructive sleep Apnoea: A bayesian meta-analysis.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Pooled it
- Effects of optimal timed automatic awakening from a short daytime nap on cognitive performance, alertness, and fatigue.Scientific reports · 2025Trial
- Intermetallic-anchored epidermal EGaIn patch with analog constriction gates for cardiorespiratory monitoring.Science advances · 2026Article
- Differential Effects of Sleep Respiratory Event Types on Heart Rate Variability: Central Apnea as the Most Significant.Diagnostics (Basel, Switzerland) · 2026Article
- Sleep Apnea and Paroxysmal Atrial Fibrillation: Diurnal Patterning of Autonomic Dysfunction and Influence of CPAP Therapy.Journal of arrhythmia · 2026Article
- Beyond the Apnea-Hypopnea Index: Circulating Biomarkers and Device-Based Metrics for Cardiometabolic Risk Stratification in Obstructive Sleep Apnea.Journal of clinical medicine · 2026Review
- Detecting sleep apnea using non-linear measures of heart rate variability.Respiratory research · 2026Article
- Electrocardiographic assessment in obstructive sleep apnea: bridging pathophysiology and clinical practice.Frontiers in physiology · 2026Article
- Heart rate variability during wakefulness reflects sleep apnea indicators but remains context-dependent.Frontiers in physiology · 2026Article
- Sleep Disturbances and Sarcopenia in Older Adults: Clinical Associations, Potential Mechanisms, and Management Strategies.International journal of general medicine · 2026Review
- An explainable deep learning approach for sleep staging in sleep apnea patients across all age subgroups from pulse oximetry signals.Engineering applications of artificial intelligence · 2025Article
- Nocturnal Heart Rate Variability in Unexplained Syncope and Sleep Apnea-The SINCOSAS Study.Journal of clinical medicine · 2025Article
- Heart rate variability analysis in comorbid insomnia and sleep apnea (COMISA).Scientific reports · 2025Observational
- Prevalence of Sleep Apnea in Patients with Syncope of Unclear Cause: SINCOSAS Study.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- [Effect of Obstructive Sleep Apnea Syndrome on Nocturnal Ambulatory Blood Pressure Monitoring Results in Older Adults Without Cardiovascular or Cerebrovascular Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Relationship between sleep-breathing events induced nocturnal blood pressure surge and sympathetic nervous activity in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Navigating Cardiovascular Challenges of Obesity: Exploring Preventive Approaches.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Association of heart rate variability with preoperative acute insomnia in patients scheduled for elective surgery.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea (OSA), a heterogeneous and multifactorial sleep related breathing disorder with high prevalence, is a recognized risk factor for cardiovascular morbidity and mortality. Autonomic dysfunction leads to adverse cardiovascular outcomes in diverse pathways. Heart rate is a complex physiological process involving neurovisceral networks and relative regulatory mechanisms such as thermoregulation, renin-angiotensin-aldosterone mechanisms, and metabolic mechanisms. Heart rate variability (HRV) is considered as a reliable and non-invasive measure of autonomic modulation response and adaptation to endogenous and exogenous stimuli. HRV measures may add a new dimension to help understand the interplay between cardiac and nervous system involvement in OSA. The aim of this review is to introduce the various applications of HRV in different aspects of OSA to examine the impaired neuro-cardiac modulation. More specifically, the topics covered include: HRV time windows, sleep staging, arousal, sleepiness, hypoxia, mental illness, and mortality and morbidity. All of these aspects show pathways in the clinical implementation of HRV to screen, diagnose, classify, and predict patients as a reasonable and more convenient alternative to current measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.