Evidence map›Paper›PMID 34366878›Full record

ArticleFrontiers in physiology2021

Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (

Mylarappa Ningappa, Morayooluwa Adenuga, Kim A Ngo, Nada Mohamed, Tejaswini Narayanan, Krishna Prasadan, Chethan Ashokkumar, Jishnu Das, Lori Schmitt, Hannah Hartman and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Mylarappa NingappaHillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.
Morayooluwa AdenugaHillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.
Kim A NgoDepartment of Bioengineering, University of California, San Diego, San Diego, La Jolla, CA, United States.
Nada MohamedDivision of Pediatric General and Thoracic Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Tejaswini NarayananDepartment of Bioengineering, University of California, San Diego, San Diego, La Jolla, CA, United States.
Krishna PrasadanRangos Research Center Animal Imaging Core, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Chethan AshokkumarHillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.
Jishnu DasHillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.
Lori SchmittHistology Core Laboratory Manager, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Hannah HartmanDivision of Pediatric General and Thoracic Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Anuradha SehrawatDivision of Pediatric General and Thoracic Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Claudia M SalgadoDivision of Pediatric Pathology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Miguel Reyes-MugicaDivision of Pediatric Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
George K GittesSurgeon-in-Chief Emeritus, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Cecilia W LoDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States.
Shankar SubramaniamDepartment of Bioengineering, University of California, San Diego, San Diego, La Jolla, CA, United States.
Rakesh SindhiHillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.
Children's Hospital of Pittsburgh · USUniversity of California, San Diego · USUniversity of Pittsburgh · US

Funding

Mapping Disease Pathways for Biliary AtresiaR01DK109365 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIN, DONGHUN, SINDHI, RAKESH K. · 2017 to 2020
$2.4M
NIDDK NIH HHS R01 DK109365
6 · The paper itself

Abstract

backgroundCiliary defects cause heterogenous phenotypes related to mutation burden which lead to impaired development. A previously reported homozygous deletion in the PURPOSE: We hypothesized that survival and lung ciliation, (a) would decrease progressively in

methods

resultsSurvival (

conclusionSurvival and lung ciliation in the

Indexed as

congenital lung and liverMan1a2 mutantsmultisystem diseaseNAC (N-acetylcysteine)prevention

Identifiers

PMID34366878
PMCPMC8343402
OpenAlexW3185991710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.