Evidence map›Paper›PMID 34366773›Full record

ArticleFrontiers in neuroscience2021

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications.

Dai Jiang, Fangqi Liu, Henry T Lancashire, Timothy A Perkins, Matthew Schormans, Anne Vanhoestenberghe, Nicholas De N Donaldson, Andreas Demosthenous

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dai JiangDepartment of Electronic and Electrical Engineering, University College London, London, United Kingdom.
Fangqi LiuDepartment of Electronic and Electrical Engineering, University College London, London, United Kingdom.
Henry T LancashireDepartment of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Timothy A PerkinsDepartment of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Matthew SchormansDepartment of Electronic and Electrical Engineering, University College London, London, United Kingdom.
Anne VanhoestenbergheDepartment of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Nicholas De N DonaldsonDepartment of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Andreas DemosthenousDepartment of Electronic and Electrical Engineering, University College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as

Indexed as

hermetic seal packageimplantable stimulatormicroelectronicspower and data telemetrywireless stimulation control

Identifiers

PMID34366773
PMCPMC8339274

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.