Evidence map›Paper›PMID 34366717›Full record

ArticleCommunications in information and systems2021

Carbohydrate-Protein Interactions: Advances and Challenges.

Shuang Zhang, Kyle Yu Chen, Xiaoqin Zou

Abstract read
In one paragraph

Article in Communications in information and systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Predictions from deep learning propose substantial protein-carbohydrate interplay.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Controlling Glycan Folding with Ionic Functional Groups.Journal of the American Chemical Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Protein-mediated interactions in the dynamic regulation of acute inflammation.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuang ZhangDalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA.
Kyle Yu ChenRock Bridge High School, 4303 South Providence Rd, Columbia, MO 65203, USA.
Xiaoqin ZouDalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA.

Funding

Structure prediction and in silico screening of protein-peptide interactionsR35GM136409 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI XIAOQIN ZOU · 2020 to 2026
$2.9M
Database and software development for protein-nucleic acid structure predicationR01GM109980 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZOU, XIAOQIN · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM109980NIGMS NIH HHS R35 GM136409
6 · The paper itself

Abstract

A carbohydrate, also called saccharide in biochemistry, is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms. For example, sugars are low molecular-weight carbohydrates, and starches are high molecular-weight carbohydrates. Carbohydrates are the most abundant organic substances in nature and essential constituents of all living things. Protein-carbohydrate interactions play important roles in many biological processes, such as cell growth, differentiation, and aggregation. They also have broad applications in pharmaceutical drug design. In this review, we will summarize the characteristic features of protein-carbohydrate interactions and review the computational methods for structure prediction, energy calculations, and kinetic studies of protein-carbohydrate complexes. Finally, we will discuss the challenges in this field.

Indexed as

Carbohydrate-protein interactionsdrug discoverymolecular dockingsaccharide-protein interactionsstructure predictionsugar-protein binding

Identifiers

PMID34366717
PMCPMC8336717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.