Evidence map›Paper›PMID 34366712›Full record

ArticleMediators of inflammation2021

Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP.

Tongzhou Liang, Jincheng Qiu, Shaoguang Li, Zhihuai Deng, Xianjian Qiu, Wenjun Hu, Pengfei Li, Taiqiu Chen, Zhancheng Liang, Hang Zhou and 4 more

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Tongzhou LiangDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Jincheng QiuDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Shaoguang LiDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Zhihuai DengDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Xianjian QiuDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Wenjun HuDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Pengfei LiDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Taiqiu ChenDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Zhancheng LiangDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Hang ZhouDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Bo GaoDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Dongsheng HuangDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.
Anjing LiangDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0001-8306-1965
Wenjie GaoDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0001-9456-8884
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. In this study, we found that ROR

Indexed as

ADAMTS4 ProteinAgedAnimalsApoptosisCell Line, TumorCell SurvivalCollagen Type IIDisease Models, AnimalFemaleHumansMagnetic Resonance ImagingMaleMatrix Metalloproteinase 13Middle AgedMolecular Docking SimulationNuclear Receptor Subfamily 1, Group F, Member 1ADAMTS4 ProteinADAMTS4 protein, humanADAMTS4 protein, ratCOL2A1 protein, humanCOL2A1 protein, ratCollagen Type IIMatrix Metalloproteinase 13MMP13 protein, humanMmp13 protein, ratNuclear Receptor Subfamily 1, Group F, Member 1Roralpha protein, ratRORA protein, humanSR 3335SulfonamidesThiophenesTumor Necrosis Factor-alphaYAP1 protein, humanYap1 protein, ratYAP-Signaling Proteins

Identifiers

PMID34366712
PMCPMC8337132
OpenAlexW3185696930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.