Evidence map›Paper›PMID 34366697›Full record

ArticleMaterials today (Kidlington, England)2021

Distributed sensor and actuator networks for closed-loop bioelectronic medicine.

Gauri Bhave, Joshua C Chen, Amanda Singer, Aditi Sharma, Jacob T Robinson

Abstract read
In one paragraph

Article in Materials today (Kidlington, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gauri BhaveRice University, Houston, TX 77005.
Joshua C ChenRice University, Houston, TX 77005.
Amanda SingerRice University, Houston, TX 77005.
Aditi SharmaRice University, Houston, TX 77005.
Jacob T RobinsonRice University, Houston, TX 77005.

Funding

Development of a Wireless Endovascular Nerve Stimulator for Treatment of Refractory Neuropathic PainU18EB029353 · NIBIB · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAN, PETER TZE MAN, ROBINSON, JACOB T. · 2019 to 2019
$2.3M
NIBIB NIH HHS U18 EB029353
6 · The paper itself

Abstract

Designing implantable bioelectronic systems that continuously monitor physiological functions and simultaneously provide personalized therapeutic solutions for patients remains a persistent challenge across many applications ranging from neural systems to bioelectronic organs. Closed-loop systems typically consist of three functional blocks, namely, sensors, signal processors and actuators. An effective system, that can provide the necessary therapeutics, tailored to individual physiological factors requires a distributed network of sensors and actuators. While significant progress has been made, closed-loop systems still face many challenges before they can truly be considered as long-term solutions for many diseases. In this review, we consider three important criteria where materials play a critical role to enable implantable closed-loop systems: Specificity, Biocompatibility and Connectivity. We look at the progress made in each of these fields with respect to a specific application and outline the challenges in creating bioelectronic technologies for the future.

Identifiers

PMID34366697
PMCPMC8336425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.