Evidence map›Paper›PMID 34366606›Full record

ReviewWorld journal of gastroenterology2021

Pancreatic cancer: A review of epidemiology, trend, and risk factors.

Jian-Xiong Hu, Cheng-Fei Zhao, Wen-Biao Chen, Qi-Cai Liu, Qu-Wen Li, Yan-Ya Lin, Feng Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 351 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
351citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

351 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Pooled it
  2. High IntratumoralInternational journal of molecular sciences · 2026
    Pooled it
  3. Pharmacological interactions between psychotropic drugs and anticancer treatments: implications for clinical practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  4. Pooled it
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  9. Artificial Intelligence in Pancreatic Imaging: A Systematic Review.United European gastroenterology journal · 2025
    Pooled it
  10. Pooled it
  11. Pooled it
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  13. Chemotherapy and radiotherapy for advanced pancreatic cancer.The Cochrane database of systematic reviews · 2024
    Pooled it
  14. Article
  15. Article
  16. Personalized neoantigen mRNA vaccines for pancreatic cancer: the role of lipid nanoparticle delivery systems.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Review

291 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jian-Xiong HuIntensive Care Unit (ICU), Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China.
Cheng-Fei ZhaoSchool of Pharmacy and Medical Technology, Putian University, Putian 351100, Fujian Province, China.
Wen-Biao ChenDepartment of Basic Medicine, Quanzhou Medical College, Quanzhou 362011, Fujian Province, China.
Qi-Cai LiuDepartment of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.
Qu-Wen LiDepartment of Priority Laboratory for Zoonoses Research, Fujian Center for Disease Control and Prevention, Fuzhou 350001, Fujian Province, China.
Yan-Ya LinIntensive Care Unit (ICU), Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China.
Feng GaoDepartment of Pathology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite rapid advances in modern medical technology and significant improvements in survival rates of many cancers, pancreatic cancer is still a highly lethal gastrointestinal cancer with a low 5-year survival rate and difficulty in early detection. At present, the incidence and mortality of pancreatic cancer are increasing year by year worldwide, no matter in the United States, Europe, Japan, or China. Globally, the incidence of pancreatic cancer is projected to increase to 18.6 per 100000 in 2050, with the average annual growth of 1.1%, meaning that pancreatic cancer will pose a significant public health burden. Due to the special anatomical location of the pancreas, the development of pancreatic cancer is usually diagnosed at a late stage with obvious clinical symptoms. Therefore, a comprehensive understanding of the risk factors for pancreatic cancer is of great clinical significance for effective prevention of pancreatic cancer. In this paper, the epidemiological characteristics, developmental trends, and risk factors of pancreatic cancer are reviewed and analyzed in detail.

Indexed as

Gastrointestinal NeoplasmsPancreatic NeoplasmsHumansIncidencePancreasRisk FactorsUnited StatesEpidemiologyPancreatic cancerPancreatic ductal adenocarcinomaRisk factorsTrend

Identifiers

PMID34366606
PMCPMC8316912

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.