ArticleJournal of geriatric oncology2022
Relationship between cognitive functioning and frailty in older breast cancer survivors.
Article in Journal of geriatric oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Association between cumulative symptom burden and cognitive impairment among breast cancer survivors: a cross-sectional study.Breast cancer research and treatment · 2026Article
- Frailty and neurocognitive impairments in Chinese survivors of childhood cancer.Journal of cancer survivorship : research and practice · 2026Article
- Effects of frailty on cognitive function in breast cancer patients: the mediating roles of nutrition and depressive symptoms.Journal of cancer survivorship : research and practice · 2026Article
- Postoperative delirium in patients with cancer: a narrative review of major risk factors.Sao Paulo medical journal = Revista paulista de medicina · 2026Review
- Transitions across the cognitive frailty spectrum and its association with anxiety in individuals aged 55 years and over: a 7 years longitudinal study.Scientific reports · 2025Article
- Importance of radiation-related cognitive decline in older adults who receive cranial radiation.Expert review of anticancer therapy · 2025Review
- Comparison of middle aged and older cancer survivors in the US Health and Retirement Study (HRS) and the Surveillance, Epidemiology, and End Results (SEER).Cancer causes & control : CCC · 2025Article
- The adverse effects of chemotherapy on bone mass are not prevented by senolytics.Scientific reports · 2025Article
- Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.Journal of cancer survivorship : research and practice · 2025Article
- The development and validation testing of a comprehensive frailty assessment in women with breast cancer.BMC women's health · 2025Article
- The National Cancer Institute clinical trials planning meeting to address gaps in observational and intervention trials for cancer-related cognitive impairment.Journal of the National Cancer Institute · 2025Article
- Effects of Breast Cancer Treatment on Neural Noise: a Longitudinal Design.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective.NPJ digital medicine · 2025Article
- A scoping review evaluating physical and cognitive functional outcomes in cancer survivors treated with chemotherapy: charting progress since the 2018 NCI think tank on cancer and aging phenotypes.Journal of cancer survivorship : research and practice · 2024Article
- Cognitive function is mediated by deficit accumulation in older, long-term breast cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- Association between Cognitive Function and Physical Function, Frailty, and Quality of Life in Older Breast Cancer Survivors.Cancers · 2024Article
- Protocol for a randomized controlled trial of brief behavioral activation among older adult cancer survivors.Journal of geriatric oncology · 2024Article
- The impact of APOE and smoking history on cognitive function in older, long-term breast cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- Prediction of cognitive decline in older breast cancer survivors: the Thinking and Living with Cancer study.JNCI cancer spectrum · 2024Article
- Cognitive function, mood and sleep changes in response to a Tai Chi/Qigong intervention among older breast cancer survivors: an exploratory analysis.Frontiers in cognition · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe relationship between cognitive function and frailty in older, long-term breast cancer survivors was examined. MATERIALS AND
methodsBreast cancer survivors who were diagnosed and treated at 60 years of age or above and were 5-15 year disease-free survivors and non-cancer controls matched on age and education were evaluated with neuropsychological tests and the Comprehensive Geriatric Assessment which was used to assess frailty based on a deficit accumulation frailty index (DAFI).
resultsUnadjusted regression analyses revealed that cancer survivors scored significantly lower on the Language (P = 0.015), Attention, Processing Speed, Executive Function (APE) (P = 0.015), and Learning and Memory (LM) (P = 0.023) domains compared to controls. However, only the LM domain remained significantly different (P = 0.002) in the adjusted analysis. Survivors had significantly higher DAFI scores compared to controls (p = 0.006) and significantly more survivors were categorized as pre-frail or frail (35%) compared to controls (23%, P = 0.009). Increasing frailty scores were associated with worse cognitive performance across all domains (all Ps ≤ 0.004). For the LM domain, there was a significant interaction (P = 0.019) between DAFI score and survivorship vs control status. Survivors demonstrated a significant linear decline in LM scores as DAFI scores increased, whereas controls demonstrated comparable scores between the robust and pre-frail DAFI groups, demonstrating decline in the frailty group only.
conclusionOlder, long-term breast cancer survivors had lower cognitive performance and higher levels of frailty compared to controls. For the Learning and Memory domain, the decline in performance began in the pre-frail range for survivors, but not controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.