Evidence map›Paper›PMID 34366241›Full record

ArticleAuris, nasus, larynx2022

Patients with COVID-19-associated olfactory impairment also show impaired trigeminal function.

Martin Sylvester Otte, Marie-Luise Bork, Philipp Heinrich Zimmermann, Jens Peter Klußmann, Jan-Christoffer Lüers

Abstract read
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In one paragraph

Article in Auris, nasus, larynx, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Taste dysfunction in Long COVID.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Martin Sylvester OtteDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne 50924, Germany. Electronic address: martin.otte@uk-koeln.de.
Marie-Luise BorkDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne 50924, Germany.
Philipp Heinrich ZimmermannDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne 50924, Germany.
Jens Peter KlußmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne 50924, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Jan-Christoffer LüersDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne 50924, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNext to olfactory function, the nose can also perceive chemestetic sensations mediated by the trigeminal nerve. While olfactory dysfunction as a symptom of COVID-19 is well described, there has been little research on the limitation of other nasal sensory inputs due to SARS-CoV-2 infection. The aim of this study was to determine possible limitations of nasal chemesthesis after COVID-19 infection by a psychophysiological diagnostic tool.

methodsIn 65 patients with a PCR-confirmed, former COVID-19 disease, olfaction was tested by means of a sniffin' sticks test, tasting by taste sprays and chemesthesis with a menthol dilution series. The subjective self-assessment of the patients was recorded via a questionnaire.

resultsWe found a restriction of nasal chemesthesis and the extent correlated with the loss of smell, as well as with the values of the taste score, but not with subjective self-assessment.

conclusionNot only the ability to smell and taste, but also nasal chemesthesis is affected by COVID-19.

Indexed as

AdultCOVID-19FemaleHumansMaleMiddle AgedOlfaction DisordersSensory ThresholdsSmellTrigeminal NerveChemesthesisSARS-CoV-2Smell disordersSniffin’ SticksTrigeminal nerve

Identifiers

PMID34366241
PMCPMC8310725

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.