ArticleJournal of Ayurveda and integrative medicine
Comparative hepatoprotective activity of detoxified roots of Plumbago zeylanica L. and Plumbago rosea L. in Wistar rats.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 11 citations in OpenAlex.
- A Case Report on Management of Liver Cirrhosis Using Ayurveda and Integrative Approach of Treatment.Case reports in hepatology · 2024Article
- Analysis of Targeted Post-operative Nursing Outcome in 1246 Patients with Percutaneous Transhepatic Biliary Drainage.Frontiers in surgery · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParacetamol (acetaminophen) toxicity is considered to be one of the major causes of drug-induced hepatic failure. Citraka (Plumbago rosea L. and Plumbago zeylanica L.) was mentioned in Ayurveda classics as a remedy in liver disorders. OBJECTIVE(S): The aim of the study was to experimentally evaluate the comparative effect of hepatoprotective activity of detoxified root decoction of the two species of Citraka against paracetamol-induced hepatotoxicity in male Wistar albino rats. MATERIALS AND
methodsThe hepatoprotective effect of Citraka decoction of two species was evaluated by the assessment of biochemical parameters such as SGOT, SGPT, alkaline phosphatase, total bilirubin, direct bilirubin, and serum creatinine. The study was also supported by histopathological assessment of liver sections.
resultsThe results showed the elevated concentration of biochemical markers and histopathological degenerative changes in animals treated with paracetamol indicating severe hepatic damage; whereas, the treatment with decoction of both the species of Citraka showed significant reduction in the serum markers and regenerative changes in the histopathological specimens pointing towards its effectiveness as a hepatoprotective drug.
conclusionThe present study showed Citraka's effectiveness as a hepatoprotective drug and proved that the detoxified root decoction of P. rosea L. has a significant protective activity against paracetamol-induced hepatotoxicity than P. zeylanica L.
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