Evidence map›Paper›PMID 34366140›Full record

ArticleMayo Clinic proceedings2021

COVID-19 in Health Care Personnel: Significance of Health Care Role, Contact History, and Symptoms in Those Who Test Positive for SARS-CoV-2 Infection.

Alexander J Lepak, Ashley Buys, Linda Stevens, Megan LeClair-Netzel, Laura Anderson, Fauzia Osman, Meghan B Brennan, Christie M Bartels, Nasia Safdar

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Mayo Clinic proceedings, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Clinical Symptom Patterns as Predictors of SARS-CoV-2 Infection in Healthcare Workers in Puerto Rico.International journal of environmental research and public health · 2025
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alexander J LepakDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: ajlepak@medicine.wisc.edu.
Ashley BuysInfection Control Department, UW Health University Hospital, Madison, WI, USA.
Linda StevensNursing Quality and Safety, UW Health University Hospital, Madison, WI, USA.
Megan LeClair-NetzelEmployee Health Services, UW Hospitals and Clinics, Madison, WI, USA.
Laura AndersonInfection Control, University of Wisconsin Medical Foundation, Inc, Madison, WI, USA.
Fauzia OsmanDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Meghan B BrennanDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Christie M BartelsDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nasia SafdarDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; William S. Middleton Memorial Veterans Affairs Medical Center, Madison, WI, USA.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Modelling applications and systems engineering to reduce infections_the MASTERI study.DP2AI144244 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SAFDAR, NASIA · 2018 to 2018
$2.3M
NCATS NIH HHS UL1 TR002373NIAID NIH HHS DP2 AI144244
6 · The paper itself

Abstract

objectiveTo identify significant factors that help predict whether health care personnel (HCP) will test positive for severe acute respiratory coronavirus 2 (SARS-CoV-2). PATIENTS AND

methodsWe conducted a prospective cohort study among 7015 symptomatic HCP from March 25, 2020, through November 11, 2020. We analyzed the associations between health care role, contact history, symptoms, and a positive nasopharyngeal swab SARS-CoV-2 polymerase chain reaction test results, using univariate and multivariable modelling.

resultsOf the symptomatic HCP, 624 (8.9%) were positive over the study period. On multivariable analysis, having a health care role other than physician or advanced practice provider, contact with family or community member with known or suspected coronavirus disease 2019 (COVID-19), and seven individual symptoms (cough, anosmia, ageusia, fever, myalgia, chills, and headache) were significantly associated with higher adjusted odds ratios for testing positive for SARS-CoV-2. For each increase in symptom number, the odds of testing positive nearly doubled (odds ratio, 1.93; 95% CI, 1.82 to 2.07, P<.001).

conclusionSymptomatic HCP have higher adjusted odds of testing positive for SARS-CoV-2 based on three distinct factors: (1) nonphysician/advanced practice provider role, (2) contact with a family or community member with suspected or known COVID-19, and (3) specific symptoms and symptom number. Differences among health care roles, which persisted after controlling for contacts, may reflect the influence of social determinants. Contacts with COVID-19-positive patients and/or HCP were not associated with higher odds of testing positive, supporting current infection control efforts. Targeted symptom and contact questionnaires may streamline symptomatic HCP testing for COVID-19.

Indexed as

PandemicsAntibodies, ViralCOVID-19COVID-19 TestingFollow-Up StudiesHealth PersonnelHumansProspective StudiesSARS-CoV-2Antibodies, Viral

Identifiers

PMID34366140
PMCPMC8249700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.