Evidence map›Paper›PMID 34366109›Full record

ArticleFertility and sterility2021

Urinary concentrations of phenols, parabens, and triclocarban in relation to uterine leiomyomata incidence and growth.

Amelia K Wesselink, Jennifer Weuve, Victoria Fruh, Traci N Bethea, Birgit Claus Henn, Quaker E Harmon, Russ Hauser, Paige L Williams, Antonia M Calafat, Michael McClean and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Bisphenol S and female reproductive toxicity: a scoping review of human studies.Journal of exposure science & environmental epidemiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts. Electronic address: akw23@bu.edu.
Jennifer WeuveDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Victoria FruhDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts.
Traci N BetheaLombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.
Birgit Claus HennDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts.
Quaker E HarmonEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Russ HauserDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Paige L WilliamsDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Antonia M CalafatNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
Michael McCleanDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts.
Donna D BairdEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Boston University · USHarvard University · USNational Institute of Environmental Health Sciences · USCenters for Disease Control and Prevention · USGeorgetown University · US

Funding

Uterine LeiomyomasZIAES049013 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JUKIC, ANNE MARIE · 2009 to 2025
$14.7M
Endocrine disrupting chemicals and risk of uterine fibroids: a prospective studyR01ES024749 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2015 to 2026
$4.8M
Intramural NIH HHS ZIA ES049013NIEHS NIH HHS R01 ES024749
6 · The paper itself

Abstract

objectiveTo examine the association of urinary concentrations of phenols, parabens, and triclocarban with incidence and growth of uterine leiomyomata (UL; fibroids).

designCase-cohort study, nested within the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study.

settingClinic visits at baseline and every 20 months for 60 months. PATIENT(S): 754 Black women aged 23-35 years residing in the Detroit, Michigan area (enrolled during 2010-2012).

interventionNone. MAIN OUTCOME MEASURE(S): At each study visit, women underwent transvaginal ultrasound for measurement of UL incidence and growth and provided urine specimens in which we quantified concentrations of seven phenols, four parabens, and triclocarban. We used Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals (CIs) characterizing the relation of urinary biomarker concentrations with UL incidence during the 60 months of follow-up. In a subset of UL detected and measured at multiple time points, we used linear regression to assess the associations between biomarker concentrations and UL growth. RESULT(S): Urinary biomarker concentrations were generally inversely associated with UL incidence, but the associations were weak and nonmonotonic. For example, hazard ratios comparing concentrations ≥90th with <50th percentile were 0.77 (95% CI: 0.46, 1.27) for bisphenol A, 0.72 (95% CI: 0.40, 1.28) for bisphenol S, and 0.76 (95% CI: 0.43, 1.33) for methylparaben. Biomarker concentrations were not strongly associated with UL growth. CONCLUSION(S): In this study of reproductive-aged Black women, urinary phenols, parabens, and triclocarban biomarkers were neither strongly nor consistently associated with UL incidence and growth.

Indexed as

AdultBiomarkers, TumorBlack or African AmericanBlack PeopleCarbanilidesCohort StudiesEnvironmental ExposureEnvironmental PollutantsFemaleFollow-Up StudiesHumansIncidenceLeiomyomaMichiganParabensPhenolsBiomarkers, TumorCarbanilidesEnvironmental PollutantsParabensPhenolstriclocarbanFibroidsparabensphenolstriclocarbanuterine leiomyomata

Identifiers

PMID34366109
PMCPMC8627427
OpenAlexW3192813181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.