Evidence map›Paper›PMID 34365905›Full record

Trial reportGut microbes

A double-blind, 377-subject randomized study identifies

M A Azcarate-Peril, J Roach, A Marsh, William D Chey, William J Sandborn, Andrew J Ritter, Dennis A Savaiano, T R Klaenhammer

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Characterization of the gut microbiome of wildFrontiers in microbiomes · 2026
    Article
  7. Article
  8. The gut microbiome connects nutrition and human health.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Regulatory T-Cells During Pregnancy Relate to Women's Own Childhood History of Microbial Exposure.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

M A Azcarate-PerilDepartment of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-0325-1289
J RoachUNC Microbiome Core, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
A MarshDepartment of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
William D CheyDepartments of Internal Medicine and Nutritional Sciences, University of Michigan Health System, Ann Arbor, MI, USA.
William J SandbornDivision of Gastroenterology, University of California San Diego, La Jolla, CA, USA.
Andrew J RitterRitter Pharmaceuticals, Inc, Los Angeles, CA, USA.
Dennis A SavaianoDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
T R KlaenhammerDepartment of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA.
University of North Carolina at Chapel Hill · USNorth Carolina State University · USPurdue University West Lafayette · USTwitter (United States) · USUniversity of California San Diego · USUniversity of Michigan · USUniversity of North Carolina at Charlotte · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ActinobacteriaDouble-Blind MethodEubacterialesGastrointestinal MicrobiomeHumansLactobacillusLactose IntoleranceOligosaccharidesPlacebosPrebioticsRNA, Ribosomal, 16SOligosaccharidesPlacebosPrebioticsRNA, Ribosomal, 16SBifidobacteriumgalacto-oligosaccharidesGOShuman lactaselactose intolerancemicrobiome modulationPrebioticsshort chain fatty acids

Identifiers

PMID34365905
PMCPMC8354614
OpenAlexW3187580812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.