ArticleMolecular neurobiology2021
Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain Injury.
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In one paragraph
Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Human Milk Bioactive Compounds and Psychomotor Outcomes in Infants and Children: A Systematic Review.Molecular nutrition & food research · 2026Pooled it
- Elovanoid neuroprotection targets cell transcriptomics and proteomics to sustain synaptic integrity after brain injury.Communications biology · 2026Article
- Lipid Messengers: Mechanisms and Clinical Applications of Exosomal Lipids in Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Sphingolipids in human disease: organ-specific pathologies, chain-length-dependent effects, and translational implications.Journal of translational medicine · 2026Review
- Oral Supplementation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Can Prevent TBI-Induced Visual, Motor, and Emotional Deficits in Mice.Molecular neurobiology · 2025Article
- Mechanistic investigation of methadone, tolfenamic acid, and cilnidipine in traumatic brain injury: a novel multi-target perspective outcome of network pharmacology.Inflammopharmacology · 2025Article
- Dietary Intake of n-3 Polyunsaturated Fatty Acids Prior to a Mild Traumatic Brain Injury Demonstrates a Dose-Response Effect for Neuroprotective Benefits in Male C57BL/6 Mice.Current developments in nutrition · 2025Article
- Fundamental Neurochemistry Review: Lipids across microglial states.Journal of neurochemistry · 2025Review
- Inhibiting De Novo Biosynthesis of Ceramide by L-Cycloserine Can Prevent Light-Induced Retinal Degeneration in Albino BALB/c Mice.International journal of molecular sciences · 2024Article
- Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases.Lipids in health and disease · 2024Article
- Sphingolipid biosynthetic inhibitor L-Cycloserine prevents oxidative-stress-mediated death in an in vitro model of photoreceptor-derived 661W cells.Experimental eye research · 2024Article
- An Open-Source Mouse Chronic EEG Array System with High-Density MXene-Based Skull Surface Electrodes.eNeuro · 2024Article
- Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury.Journal of neurochemistry · 2023Review
- Engineered Mesenchymal Stem Cells Over-Expressing BDNF Protect the Brain from Traumatic Brain Injury-Induced Neuronal Death, Neurological Deficits, and Cognitive Impairments.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- Relationships between ocular surface sphingomyelinases, Meibum and Tear Sphingolipids, and clinical parameters of meibomian gland dysfunction.The ocular surface · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Koushik MondalDepartment of Ophthalmology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA.
Haruka TakahashiDepartment of Ophthalmology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA.
Jerome ColeDepartment of Ophthalmology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA.
Nobel A Del MarDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA.
Chunyan LiDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA.
Daniel J StephensonDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA.
Jeremy AllegoodDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, 23219, USA.
L Ashley CowartDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, 23219, USA.
Charles E ChalfantDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA.
Anton ReinerDepartment of Ophthalmology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA.
Nawajes MandalDepartment of Ophthalmology, The University of Tennessee Health Science Centre, TN, 38163, Memphis, USA. nmandal@uthsc.edu.ORCID http://orcid.org/0000-0003-4489-7748
University of Tennessee Health Science Center · USUniversity of South Florida · USVirginia Commonwealth University · US
Funding
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0MThe roles of ceramide and its derivatives in A. phagocytophilum pathogenesisR01AI139072 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARLES E. CHALFANT, Jason A Carlyon · 2018 to 2026
$5.7MNEURAL CONTROL OF CHOROIDAL BLOOD FLOW IN THE EYER01EY005298 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI REINER, ANTON J. · 1985 to 2019
$4.9MThe utilization of photonics technology to rapidly detect bioactive lipids associated with preeclampsia developmentU01HD087198 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E., WALSH, SCOTT W · 2015 to 2015
$4.2MiPLA2beta-mediated alternative splicing and -cell death in type 1 diabetesR01DK126444 · NIDDK · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., EIZIRIK, DECIO LAKS · 2021 to 2024
$2.0MThe role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healingR01GM137394 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., KORDULA, TOMASZ K · 2021 to 2024
$1.9MSphingolipids and their Impact in Corneal Wound HealingR01EY031316 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KARAMICHOS, DIMITRIOS, MANDAL, NAWAJES · 2020 to 2023
$1.8MSphingolipid Metabolism and Signaling in the RetinaR01EY022071 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MANDAL, NAWAJES · 2012 to 2016
$1.8MThe role of ceramide kinase in mitophagyR01GM137578 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E. · 2020 to 2023
$1.3MThe role of RNA splicing in non-small cell lung cancerI01BX001792 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2013 to 2024
–Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunctionI01BX004893 · VA · MIAMI VA HEALTH CARE SYSTEM · PI GALOR, ANAT, MANDAL, NAWAJES · 2021 to 2025
–BLRD Research Career Scientist Award ApplicationIK6BX004603 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2019 to 2025
–BLRD VA I01 BX001792BLRD VA I01 BX004893BLRD VA IK6 BX004603Congressionally Directed Medical Research Programs W81XWH-16-1-0076Congressionally Directed Medical Research Programs W81XWH-20-1-0900NCI NIH HHS P30 CA016059NEI NIH HHS R01 EY005298NEI NIH HHS R01 EY022071NEI NIH HHS R01 EY031316NIAID NIH HHS R01 AI139072NIDDK NIH HHS R01 DK126444NIGMS NIH HHS R01 GM137394NIGMS NIH HHS R01 GM137578NIH HHS AI139072NIH HHS CA016059NIH HHS EY005298NIH HHS EY022071NIH HHS EY031316NIH HHS GM137394NIH HHS GM137578U.S. Department of Veterans Affairs BX001792U.S. Department of Veterans Affairs BX004893
Abstract
Traumatic brain injury (TBI) causes neuroinflammation and neurodegeneration leading to various pathological complications such as motor and sensory (visual) deficits, cognitive impairment, and depression. N-3 polyunsaturated fatty acid (n-3 PUFA) containing lipids are known to be anti-inflammatory, whereas the sphingolipid, ceramide (Cer), is an inducer of neuroinflammation and degeneration. Using Fat1
Indexed as
Affective SymptomsAnimalsBrain ChemistryBrain ConcussionCadherinsCeramidesDepressionDisease ResistanceFatty Acids, Omega-3FearFemaleHead Injuries, ClosedMaleMiceMice, Inbred C57BLMice, TransgenicCadherinsCeramidesfat1 protein, mouseFatty Acids, Omega-3Recombinant ProteinsSphingolipidsSphingomyelin PhosphodiesteraseCeramideEmotional deficitsFearfulnessn-3 PUFANeuroinflammationTraumatic brain injury (TBI)Visual deficits
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.