Evidence map›Paper›PMID 34365536›Full record

ArticleDigestive diseases and sciences2022

Comorbidities Associated with Worse Outcomes Among Inpatients Admitted for Acute Gastrointestinal Bleeding.

K Siebenhüner, J Blaser, A Nowak, M Cheetham, B U Mueller, E Battegay, P E Beeler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K SiebenhünerInstitute of Epidemiology, Biostatistics and Prevention, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland. klarissa.siebenhuener@uzh.ch.ORCID 0000-0002-3414-3152
J BlaserDirectorate of Research and Education, University Hospital of Zurich, Zurich, Switzerland.
A NowakDepartment of Endocrinology and Clinical Nutrition, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4119-5516
M CheethamDepartment of Internal Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
B U MuellerDepartment of Internal Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
E BattegayDepartment of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland.
P E BeelerInstitute of Epidemiology, Biostatistics and Prevention, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland.ORCID 0000-0002-6097-2480

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultimorbidity increases healthcare resource utilization. Little is known on specific comorbidity combinations.

aimsTo identify comorbidities associated with increased resource utilization among inpatients admitted for gastrointestinal bleeding (GIB).

methodsThis retrospective cross-sectional study, 1/2010-5/2018 at the University Hospital Zurich, Switzerland, analyzed electronic health records of patients with upper (UGIB) and lower (LGIB) GIB, focusing on length of stay (LOS) and 30-day readmissions for resource use and clinical outcomes, investigated by multivariable regression adjusted for antithrombotics.

resultsOf 1101 patients, 791 had UGIB and 310 LGIB, most often melena and bleeding diverticula, respectively. In UGIB, thromboembolic events showed a trend toward 27% increased LOS (1.27; 95% confidence interval [CI] 1.00-1.61), antithrombotics independently associated with 46% increased LOS (1.46; 95% CI 1.32-1.62). Cancer (odds ratio [OR] 2.86; 95% CI 1.68-4.88) independently associated with 30-day readmissions, anemia showed a trend (OR 1.68; 95% CI 1.00-2.84). In LGIB, none of the investigated comorbidities associated with increased LOS, but antithrombotics independently associated with 25% increased LOS (1.25; 95% CI 1.07-1.46). Atrial fibrillation/flutter (OR 2.69; 95% CI 1.06-6.82) and cancer (OR 4.76; 95% CI 1.40-16.20) associated strongly with 30-day readmissions.

conclusionsIn both groups, cancer associated with 30-day readmissions, antithrombotics with increased LOS. Thromboembolic events and anemia showed clinically important trends in UGIB. Atrial fibrillation/flutter associated with 30-day readmissions in LGIB. Prospective studies are needed to investigate these complex multimorbid populations and establish appropriate guidelines.

Indexed as

Atrial FibrillationInpatientsAcute DiseaseComorbidityCross-Sectional StudiesFibrinolytic AgentsGastrointestinal HemorrhageHumansLength of StayRetrospective StudiesRisk FactorsFibrinolytic AgentsComorbidityGastrointestinal bleedingInpatientsLength of stayMultimorbidityPatient readmission

Identifiers

PMID34365536
PMCPMC8349143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.