Evidence map›Paper›PMID 34365456›Full record

ArticleSkin pharmacology and physiology2021

The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study.

Annika van Welzen, Matti Hoch, Philip Wahl, Frank Weber, Susen Rode, Julia Katharina Tietze, Lars Boeckmann, Steffen Emmert, Alexander Thiem

Erratum issuedOpen access · hybridAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Skin pharmacology and physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Penetration depth of cold atmospheric plasma into biological tissue: a review.Frontiers in bioengineering and biotechnology · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Biofilm · 2023
    Article
  12. Review
  13. Review
  14. Review
  15. [Wound therapy with cold atmospheric plasma in severe recessive dystrophic epidermolysis bullosa : A pilot study].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Article
  16. Article
  17. Tolerance effect of a shock-free atmospheric plasma on human skin.Applied physics. A, Materials science & processing · 2022
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Annika van WelzenClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Matti HochDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.
Philip WahlDiaspective Vision GmbH, Pepelow, Germany.
Frank WeberDepartment for Biostatistics and Informatics in Medicine, University Medical Center, Rostock, Germany.
Susen RodeClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Julia Katharina TietzeClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Lars BoeckmannClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Steffen EmmertClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Alexander ThiemClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
University of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCold atmospheric plasma (CAP) has positive effects on wound healing and antimicrobial properties. However, an ongoing challenge is the development of specific modes of application for different clinical indications.

objectivesWe investigated in a prospective pilot study the response and tolerability of a newly developed CAP wound dressing for the acute healing of split skin graft donor sites compared to conventional therapy.

methodsWe applied both treatments to each patient (n = 10) for 7 days and measured 4 parameters of wound healing every other day (i.e., 1,440 measurements) using a hyperspectral imaging camera. Additionally, we evaluated the clinical appearance and pain levels reported by the patients.

resultsThe CAP wound dressing was superior to the control (p < 0.001) in the improvement of 3 wound parameters, that is, deep tissue oxygen saturation, hemoglobin distribution, and tissue water distribution. CAP was well tolerated, and pain levels were lower in CAP-treated wound areas.

conclusionCAP wound dressing is a promising new tool for acute wound healing.

Indexed as

Plasma GasesSkin TransplantationBandagesHumansOxygen SaturationPilot ProjectsProspective StudiesWound HealingPlasma GasesAcute wound healingCold atmospheric plasmaHyperspectral imagingPlasma medicinePlasma therapySplit skin graft donor siteWound dressing

Identifiers

PMID34365456
PMCPMC8619757
OpenAlexW3190072066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.