Observational studyPlacenta2021
Normative placental structure in pregnancy using quantitative Magnetic Resonance Imaging.
Observational study in Placenta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Recent innovations in placental MRI: Integrating visualization and functional imaging.Placenta · 2026Review
- Charting normative reference values and Z-scores for MRI-derived in vivo placental growth.Pediatric radiology · 2026Observational
- Placental MRI texture features in prenatal exposure to opioids and tobacco.Scientific reports · 2025Article
- Morphological Macroscopical Placental Features of Pregnancies Complicated with Fetal Growth Restriction: a Case-Control Study.Maedica · 2025Article
- Neurodevelopmental Outcomes of Preschoolers with Antenatal Zika Virus Exposure Born in the United States.Pathogens (Basel, Switzerland) · 2024Article
- Placental size at gestational week 36: Comparisons between ongoing pregnancies and deliveries.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Placental volume in pregnant women with opioid use: prenatal MRI assessment.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Reliability and Feasibility of Low-Field-Strength Fetal MRI at 0.55 T during Pregnancy.Radiology · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
introductionTo characterize normative morphometric, textural and microstructural placental development by applying advanced and quantitative magnetic resonance imaging (qMRI) techniques to the in-vivo placenta.
methodsWe enrolled 195 women with uncomplicated, healthy singleton pregnancies in a prospective observational study. Women underwent MRI between 16- and 40-weeks' gestation. Morphometric and textural metrics of placental growth were calculated from T2-weighted (T2W) images, while measures of microstructural development were calculated from diffusion-weighted images (DWI). Normative tables and reference curves were constructed for each measured index across gestation and according to fetal sex.
resultsData from 269 MRI studies from 169 pregnant women were included in the analyses. During the study period, placentas undergo significant increases in morphometric measures of volume, thickness, and elongation. Placental texture reveals increasing variability with advancing gestation as measured by grey level non uniformity, run length non uniformity and long run high grey level emphasis. Placental microstructure did not vary with gestational age. Placental elongation was the only metric that differed significantly between male and female fetuses. DISCUSSION: We report quantitative metrics of placental morphometry, texture and microstructure in a large cohort of healthy controls during the second and third trimesters of pregnancy. These measures can serve as normative references of in-vivo placental development to better understand placental function in high-risk conditions and allow for the early detection of placental mal-development.
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