ReviewCurrent opinion in microbiology2021
Hierarchical and simultaneous utilization of carbon substrates: mechanistic insights, physiological roles, and ecological consequences.
Review in Current opinion in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments.PLoS computational biology · 2026Article
- Real-time simultaneous monitoring of multiple analytes in bacterial cultures.Applied and environmental microbiology · 2025Article
- Aromatic acid metabolism inApplied and environmental microbiology · 2025Article
- Genomic prediction of symbiotic interactions between two Endozoicomonas clades and their coral host, Acropora loripes.Animal microbiome · 2025Article
- Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources.mSystems · 2025Article
- Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering.Cell host & microbe · 2025Review
- The type of carbon source not the growth rate it supports can determine diauxie in Saccharomyces cerevisiae.Communications biology · 2025Article
- Making sense of gene expression control by flux sensing.Nature metabolism · 2025Article
- L-Rhamnose Globally Changes the Transcriptome of Planktonic and BiofilmMicroorganisms · 2024Article
- Enhancement of lactate fraction in poly(lactate-co-3-hydroxybutyrate) biosynthesized by metabolically engineered E. coli.Bioresources and bioprocessing · 2024Article
- Starvation responses impact interaction dynamics of human gut bacteria Bacteroides thetaiotaomicron and Roseburia intestinalis.The ISME journal · 2023Article
- The Architecture of Metabolic Networks Constrains the Evolution of Microbial Resource Hierarchies.Molecular biology and evolution · 2023Article
- Shaping bacterial gene expression by physiological and proteome allocation constraints.Nature reviews. Microbiology · 2023Review
- The importance of understanding the regulation of bacterial metabolism.Environmental microbiology · 2023Article
- Regulation of hierarchical carbon substrate utilization, nitrogen fixation, and root colonization by the Hfq/Crc/CrcZY genes iniScience · 2022Article
- Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback.Nucleic acids research · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bacteria grown on a mixture of carbon substrates exhibit two utilization patterns: hierarchical utilization (HU) and simultaneous utilization (SU). How and why cells adopt these different behaviors remains poorly understood despite decades of research. Recent studies address various open questions from multiple viewpoints. From a mechanistic perspective, it was found that flux sensors play a central role in the regulation of substrate utilization, accounting for the known dependences on single-substrate growth rates, substrate concentrations, and the point where the substrate enters central metabolism. From a physiological perspective, several recent studies suggested HU or SU as growth-optimizing strategies through efficient allocation of essential proteome resources. However, other studies demonstrate that a significant fraction of the proteome is dedicated to functions apparently unnecessary for growth, casting doubt on explanations based on slight efficiency gains. From an ecological perspective, recent theoretical studies suggest that HU can help increase species diversity in bacterial communities.
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Registered trials
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