Evidence map›Paper›PMID 34364993›Full record

Trial reportNeuroImage2021

Magnetization transfer weighted EPI facilitates cortical depth determination in native fMRI space.

Yuhui Chai, Linqing Li, Yicun Wang, Laurentius Huber, Benedikt A Poser, Jeff Duyn, Peter A Bandettini

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yuhui ChaiSection on Functional Imaging Methods, Laboratory of Brain and Cognition, NIMH, NIH, Bethesda 20892, MD, United States. Electronic address: yuhui.chai@nih.gov.
Linqing LiFunctional MRI Core, NIMH, NIH, Bethesda, MD, United States.
Yicun WangAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States.
Laurentius HuberMaastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, University of Maastricht, the Netherlands.
Benedikt A PoserMaastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, University of Maastricht, the Netherlands.
Jeff DuynAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States.
Peter A BandettiniSection on Functional Imaging Methods, Laboratory of Brain and Cognition, NIMH, NIH, Bethesda 20892, MD, United States; Functional MRI Core, NIMH, NIH, Bethesda, MD, United States.
National Institutes of Health · USMaastricht University · NL

Funding

Functional MRI Method DevelopmentZIAMH002783 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BANDETTINI, PETER · 2009 to 2025
$38.4M
Magnetic Resonance Imaging Technology DevelopmentZIANS002990 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DUYN, JEFF · 2009 to 2025
$25.5M
Foundations of MRI Corticography for mesoscale organization and neuronal circuitryR01MH111444 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN · 2016 to 2020
$5.1M
Intramural NIH HHS ZIA MH002783NIMH NIH HHS R01 MH111444
6 · The paper itself

Abstract

The increased availability of ultra-high field scanners provides an opportunity to perform fMRI at sub-millimeter spatial scales and enables in vivo probing of laminar function in the human brain. In most previous studies, the definition of cortical layers, or depths, is based on an anatomical reference image that is collected by a different acquisition sequence and exhibits different geometric distortion compared to the functional images. Here, we propose to generate the anatomical image with the fMRI acquisition technique by incorporating magnetization transfer (MT) weighted imaging. Small flip angle binomial pulse trains are used as MT preparation, with a flexible duration (several to tens of milliseconds), which can be applied before each EPI segment without constraining the acquisition length (segment or slice number). The method's feasibility was demonstrated at 7T for coverage of either a small slab or the near-whole brain at 0.8 mm isotropic resolution. Tissue contrast was found to be similar to that obtained with a state-of-art anatomical reference based on MP2RAGE. This MT-weighted EPI image allows an automatic reconstruction of the cortical surface to support laminar analysis in native fMRI space, obviating the need for distortion correction and registration.

Indexed as

Brain MappingCerebral CortexEcho-Planar ImagingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingCortical layerDepthfMRILaminarLayerMagnetization transfer

Identifiers

PMID34364993
PMCPMC8520138
OpenAlexW3192199481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.