Evidence map›Paper›PMID 34364955›Full record

ArticleNeuroscience2022

Do Biological Constraints Impair Dendritic Computation?

Ilenna Simone Jones, Konrad Paul Kording

Open access · greenAbstract read
In one paragraph

Article in Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. How far neuroscience is from understanding brains.Frontiers in systems neuroscience · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ilenna Simone JonesDepartment of Neuroscience, University of Pennsylvania, United States. Electronic address: ilennaj@pennmedicine.upenn.edu.
Konrad Paul KordingDepartment of Neuroscience, University of Pennsylvania, United States; Department Bioengineering, University of Pennsylvania, United States.
University of Pennsylvania · US

Funding

Quantifying causality for neuroscienceR01EB028162 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI KORDING, KONRAD P. · 2019 to 2019
$1.1M
Howard Hughes Medical InstituteNIBIB NIH HHS R01 EB028162
6 · The paper itself

Abstract

Computations on the dendritic trees of neurons have important constraints. Voltage dependent conductances in dendrites are not similar to arbitrary direct-current generation, they are the basis for dendritic nonlinearities and they do not allow converting positive currents into negative currents. While it has been speculated that the dendritic tree of a neuron can be seen as a multi-layer neural network and it has been shown that such an architecture could be computationally strong, we do not know if that computational strength is preserved under these biological constraints. Here we simulate models of dendritic computation with and without these constraints. We find that dendritic model performance on interesting machine learning tasks is not hurt by these constraints but may benefit from them. Our results suggest that single real dendritic trees may be able to learn a surprisingly broad range of tasks.

Indexed as

DendritesModels, NeurologicalAction PotentialsNeural Networks, ComputerNeuronsSynapsesdendritic computationion channelsmachine learningmodelingnonlinearity

Identifiers

PMID34364955
PMCPMC8835230
OpenAlexW3134321088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.