Evidence map›Paper›PMID 34364544›Full record

ReviewThe lancet. Gastroenterology & hepatology2021

Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement.

Mohammed Eslam, Naim Alkhouri, Pietro Vajro, Ulrich Baumann, Ram Weiss, Piotr Socha, Claude Marcus, Way Seah Lee, Deirdre Kelly, Gilda Porta and 7 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in The lancet. Gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 7 pooled it
28.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 7 syntheses or guidelines pooled it, 259 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. The egyptian clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Guideline
  8. Trial
  9. Article
  10. Review
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 11 countries.

Mohammed EslamStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Sydney, NSW, Australia. Electronic address: mohammed.eslam@sydney.edu.au.
Naim AlkhouriDepartment of Hepatology, Arizona Liver Health, Chandler, AZ, USA.
Pietro VajroDepartment of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.
Ulrich BaumannDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Ram WeissDepartment of Pediatrics, Ruth Rappaport Children's Hospital, Rambam Medical Center, Technion School of Medicine, Haifa, Israel.
Piotr SochaDepartment of Gastroenterology, Hepatology, Nutritional Disorders and Paediatrics, Children's Memorial Health Institute, Warsaw, Poland.
Claude MarcusDivision of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Way Seah LeeDepartment of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Deirdre KellyThe Liver Unit, Birmingham Women's & Children's Hospital, University of Birmingham, Birmingham, UK.
Gilda PortaPediatric Hepatology, Transplant Unit, Hospital Sírio-Libanês, Hospital Municipal Infantil Menino Jesus, San Paulo, Brazil.
Mohamed A El-GuindiDepartment of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
Anna AlisiResearch Unit of Molecular Genetics and Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Jake P MannMetabolic Research Laboratories, Institute of Metabolic Science, and Department of Paediatrics, University of Cambridge, Cambridge, UK.
Nezha MouaneDepartment of Pediatric Hepatology, Gastroenterology and Nutrition, Academic Children's Hospital, Mohammed V University, Rabat, Morocco; Department of Pediatric Hepatology, Gastroenterology and Nutrition, Children's Hospital of Rabat, Rabat, Morocco.
Louise A BaurChildren's Hospital Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Anil DhawanPaediatric Liver, GI and Nutrition Centre, and MowatLabs, King's College Hospital, London, UK.
Jacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Sydney, NSW, Australia.
The University of Sydney · AUArizona Liver Health · USBambino Gesù Children's Hospital · ITChildren's Memorial Health Institute · PLHospital Sírio-Libanês · BRKarolinska Institutet · SEKing's College Hospital · GBMedizinische Hochschule Hannover · DEMenoufia University · EGMohammed V University · MAUniversity of Birmingham · GBUniversity of Malaya · MYUniversity of Salerno · ITWellcome/MRC Institute of Metabolic Science · GBWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for both adults and children. The definition is most problematic for children, for whom alcohol consumption is usually not a concern. This problematic definition has prompted a consensus to rename and redefine adult NAFLD associated with metabolic dysregulation to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Similarities, distinctions, and differences exist in the causes, natural history, and prognosis of fatty liver diseases in children compared with adults. In this Viewpoint we, an international panel, propose an overarching framework for paediatric fatty liver diseases and an age-appropriate MAFLD definition based on sex and age percentiles. The framework recognises the possibility of other coexisting systemic fatty liver diseases in children. The new MAFLD diagnostic criteria provide paediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, and they align with a definition that is valid across the lifespan.

Indexed as

AdolescentAdultChildConsensusDisease ProgressionFemaleHumansInsulin ResistanceInterdisciplinary CommunicationMaleMetabolic SyndromeNon-alcoholic Fatty Liver DiseaseObesityPrevalencePrognosisRandomized Controlled Trials as Topic

Identifiers

PMID34364544
OpenAlexW3187910690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.