ReviewThe Lancet. Infectious diseases2021
Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Erratum issuedAbstract readReview
In one paragraph
Review in The Lancet. Infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 160 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
160 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Histoplasmosis: A systematic review to inform the World Health Organization of a fungal priority pathogens list.Medical mycology · 2024Pooled it
- Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.Mycopathologia · 2023Pooled it
- Hypoxemic Respiratory Failure and Coccidioidomycosis-Associated Acute Respiratory Distress Syndrome.Open forum infectious diseases · 2024Trial
- Fosmanogepix Treatment for Coccidioidomycosis Under an Expanded Access Program.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Development and Clinical Evaluation of a Novel Talaromyces marneffei Mp1p Lateral Flow Assay for Rapid Diagnosis of Talaromycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Disseminated Blastomycosis With Pulmonary, Cutaneous, and Splenic Involvement in a Construction Worker: A Case Report.Clinical case reports · 2026Article
- Localized Cutaneous Versus Deep Sporotrichosis at Hospital das Clínicas, UFMG, Belo Horizonte, Brazil: A Cohort of 213 Culture-Confirmed Cases, 2011 to 2026.Journal of fungi (Basel, Switzerland) · 2026Article
- Man-in-the-barrel syndrome caused by cervical arachnoiditis in refractory coccidioidal meningitis.Medical mycology case reports · 2026Article
- Prognosis of Patients Infected WithJournal of general and family medicine · 2026Article
- Therapeutic Failure in Invasive Fungal Infections: Beyond Antifungal Resistance-A Narrative Review.Journal of fungi (Basel, Switzerland) · 2026Review
- 30 years in service, 1996-2026: Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of hematology · 2026Review
- Regional Heterogeneity and Temporal Trends of Infant-Juvenile Paracoccidioidomycosis in Argentina: A 15-Year Comparative Study.Journal of fungi (Basel, Switzerland) · 2026Article
- Asian consensus on diagnostic algorithm for invasive pulmonary fungal diseases in high-burden settings.Journal of translational internal medicine · 2026Article
- Fungal diagnostics and antifungal drug access in Latin America and the Caribbean: an ESCMID EFISG multinational survey.Nature communications · 2026Article
- Emergence of feline sporotrichosis with zoonotic risk in a municipality of the Eastern Amazon, Brazil.Companion animal health and genetics · 2026Article
- Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies.Journal of fungi (Basel, Switzerland) · 2026Review
- Paracoccidioidomycosis in Brazil: 25-Year Nationwide Trends in Mortality, Hospitalisations and In-Hospital Deaths of a Neglected Systemic Mycosis.Tropical medicine & international health : TM & IH · 2026Article
- In Vitro Evaluation of Olorofim and Amphotericin B Combination Therapy AgainstJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
39 authors.
George R ThompsonDepartment of Internal Medicine, Division of Infectious Disease, UC Davis Medical Center, Sacramento, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA. Electronic address: grthompson@ucdavis.edu.
Thuy LeDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Ariya ChindampornDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Carol A KauffmanVA Ann Arbor Healthcare System, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA.
Ana Alastruey-IzquierdoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Neil M AmpelDivision of Infectious Diseases, Mayo Clinic, Phoenix, AZ, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Arizona College of Medicine, Tucson, AZ, USA.
David R AndesDepartment of Internal Medicine, Division of Infectious Diseases, and Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA.
Darius Armstrong-JamesDepartment of Infectious Diseases, Imperial College London, London, UK.
Olusola AyanlowoDepartment of Medicine, Faculty of Clinical Sciences, University of Lagos, Lagos, Nigeria.
John W BaddleyDepartment of Internal Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, USA.
Bridget M BarkerPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Leila Lopes BezerraCellular Mycology and Proteomics Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Maria J BuitragoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Leili Chamani-TabrizInfectious Diseases Unit, Department of Internal Medicine, Saudi German Hospital Dubai, Dubai, UAE.
Jasper F W ChanState Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Methee ChayakulkeereeDivision of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Oliver A CornelyDepartment of Internal Medicine, Excellence Center for Medical Mycology, University Hospital of Cologne, Cologne, Germany; Department of Internal Medicine, Division of Infectious Diseases, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Cao CunweiDepartment of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jean-Pierre GangneuxDepartment of Internal Medicine, Division of Infectious Diseases, Rennes University, CHU Rennes, Inserm, IRSET-UMR_S 1085, Rennes, France.
Nelesh P GovenderNational Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa; Department of Internal Medicine, Division of Infectious Diseases, University of the Witwatersrand, Johannesburg, South Africa.
Ferry HagenWesterdijk Fungal Biodiversity Institute, Utrecht, Netherlands; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands; Laboratory of Medical Mycology, Jining No 1 People's Hospital, Jining, China.
Mohammad T HedayatiDepartment of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Tobias M HohlInfectious Disease Service, Department of Medicine; Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology Program, Sloan Kettering Institute, New York, NY, USA.
Grégory JouvionSorbonne Université, INSERM, Pathophysiology of Pediatric Genetic Diseases, Assistance Publique-Hôpitaux de Paris, Hôpital Armand-Trousseau, UF Génétique Moléculaire, Paris, France; Institut Pasteur, Experimental Neuropathology Unit, Paris, France.
Chris KenyonInstitute of Tropical Medicine, Antwerp, Belgium.
Christopher C KibblerCentre for Medical Microbiology, University College London, London, UK.
Nikolai KlimkoDepartment of Clinical Mycology, Allergy, and Immunology, I Mechnikov North-Western State Medical University, St Petersburg, Russia.
David C M KongPharmacy Department, Ballarat Health Services, Ballarat, VIC, Australia; National Centre for Antimicrobial Stewardship, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Robert KrauseSection of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Low Lee LeeDepartment of Internal Medicine, Hospital Sultanah Bayiyah, Alor Setar, Kedah, Malaysia.
Graeme MeintjesWellcome Centre for Infectious Diseases Research, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa.
Marisa H MiceliDepartment of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA.
Peter-Michael RathInstitute of Medical Microbiology, University Hospital Essen, Essen, Germany.
Andrej SpecDivision of Infectious Disease, Washington University School of Medicine, St Louis, MO, USA.
Flavio Queiroz-TellesDepartment of Public Health, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.
Ebrahim VariavaDepartment of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Paul E VerweijDepartment of Medical Microbiology, Excellence Center for Medical Mycology, Radboudumc-CWZ Center of Expertise for Mycology, Radboud University Medical Center, Nijmegen, Netherlands.
Ilan S SchwartzDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Alessandro C PasqualottoDepartment of Clinical Medicine, Federal University of Health Sciences of Porto Alegre Porto Alegre, Brazil; Molecular Biology Laboratory, Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MSocial and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5MNovel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3MINITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR37AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2021 to 2026
$4.2MAntifungal Immunity and the Mechanism of Fungal Programmed Cell DeathR01AI139632 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CRAMER, ROBERT ANDREW, HOHL, TOBIAS M · 2019 to 2023
$3.3MMaking an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaR01AI143409 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2019 to 2024
$2.8MTropical Medicine Research Center for Talaromycosis in VietnamU01AI169358 · NIAID · DUKE UNIVERSITY · PI Thuy Le · 2022 to 2026
$2.5MImplications of mycoviral infection in Talaromyces marneffei: an analysis of human patient samples, RNAi, and hypermutationR21AI159397 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH, LE, THUY · 2021 to 2022
$443kMapping of the IgM and IgG antibody responses to Talaromyces marneffei infection in mice and humans - Deciphering acute from reactivated or latent infectionsR21AI162367 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2021 to 2022
$434kNCI NIH HHS P30 CA008748NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI063503NIAID NIH HHS R01 AI139632NIAID NIH HHS R01 AI143409NIAID NIH HHS R21 AI159397NIAID NIH HHS R21 AI162367NIAID NIH HHS R37 AI093808NIAID NIH HHS U01 AI169358
Abstract
The global burden of the endemic mycoses (blastomycosis, coccidioidomycosis, emergomycosis, histoplasmosis, paracoccidioidomycosis, sporotrichosis, and talaromycosis) continues to rise yearly and these infectious diseases remain a leading cause of patient morbidity and mortality worldwide. Management of the associated pathogens requires a thorough understanding of the epidemiology, risk factors, diagnostic methods and performance characteristics in different patient populations, and treatment options unique to each infection. Guidance on the management of these infections has the potential to improve prognosis. The recommendations outlined in this Review are part of the "One World, One Guideline" initiative of the European Confederation of Medical Mycology. Experts from 23 countries contributed to the development of these guidelines. The aim of this Review is to provide an up-to-date consensus and practical guidance in clinical decision making, by engaging physicians and scientists involved in various aspects of clinical management.
Indexed as
Clinical Decision-MakingEndemic DiseasesGlobal HealthGuidelines as TopicInternational CooperationMycosesAnimalsConsensusEuropeHumansRisk Factors
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