Evidence map›Paper›PMID 34363916›Full record

ArticleInternational journal of pharmaceutics2021

Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death.

Xuejia Kang, Yuxin Cai, Qi Wang, Chuanyu Wang, Wu Chen, Wen Yang, Amol Suryawanshi, Gang Zhou, Pengyu Chen, Feng Li

Open access · greenAbstract read
In one paragraph

Article in International journal of pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Copper Homeostasis, Emerging Central Players in Cancer Immunotherapy.Journal of cellular and molecular medicine · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xuejia KangDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849 USA.
Yuxin CaiMaterials Research and Education Center, Materials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL 36849 USA.
Qi WangDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849 USA.
Chuanyu WangMaterials Research and Education Center, Materials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL 36849 USA.
Wu ChenDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849 USA.
Wen YangMaterials Research and Education Center, Materials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL 36849 USA.
Amol SuryawanshiDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 USA.
Gang ZhouGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912 USA.
Pengyu ChenMaterials Research and Education Center, Materials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL 36849 USA.
Feng LiDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849 USA. Electronic address: FZL0023@auburn.edu.
Auburn University · USAugusta University · US

Funding

Purchase of a modularized confocal microscopeR35GM133795 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI Pengyu Chen · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM133795
6 · The paper itself

Abstract

Disulfiram copper complex [Cu(DDC)

Indexed as

NanoparticlesNeoplasmsProdrugsCell Line, TumorCopperDrug CombinationsImmunogenic Cell DeathInfrared RaysCopperDrug CombinationsProdrugsCuS nanoparticlesDisulfiram prodrugImmunogenic cell death (ICD)Near-infrared laserReactive oxygen species (ROS)

Identifiers

PMID34363916
PMCPMC8567724
OpenAlexW3192595480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.