Evidence map›Paper›PMID 34363749›Full record

ArticleImmunity2021

Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress.

Rysa Zaman, Homaira Hamidzada, Crystal Kantores, Anthony Wong, Sarah A Dick, Yiming Wang, Abdul Momen, Laura Aronoff, Julia Lin, Babak Razani and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 131 citations in OpenAlex.

  1. Article
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  5. Neurovascular interactions in the ageing heart.Nature reviews. Cardiology · 2026
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  6. Macrophages and the Survival of Cardiomyocytes After Myocardial Infarction.Arteriosclerosis, thrombosis, and vascular biology · 2026
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  7. Review
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  10. Review
  11. Regenerative therapy · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Rysa ZamanToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Homaira HamidzadaToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Crystal KantoresToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Anthony WongToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Sarah A DickToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada.
Yiming WangToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Abdul MomenToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Laura AronoffToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Julia LinToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Babak RazaniDivision of Cardiology, Washington University School of Medicine, St. Louis, MO, USA.
Seema MitalTed Rogers Centre for Heart Research, Toronto, ON, Canada; Division of Cardiology, Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
Filio BilliaToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada.
Kory J LavineDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Sara NejatToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada.
Slava EpelmanToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada. Electronic address: slava.epelman@uhn.ca.
University Health Network · CATed Rogers Centre for Heart Research · CAUniversity of Toronto · CAWashington University in St. Louis · US

Funding

The Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6M
MACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9M
MACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL151078
6 · The paper itself

Abstract

Hypertension affects one-third of the world's population, leading to cardiac dysfunction that is modulated by resident and recruited immune cells. Cardiomyocyte growth and increased cardiac mass are essential to withstand hypertensive stress; however, whether immune cells are involved in this compensatory cardioprotective process is unclear. In normotensive animals, single-cell transcriptomics of fate-mapped self-renewing cardiac resident macrophages (RMs) revealed transcriptionally diverse cell states with a core repertoire of reparative gene programs, including high expression of insulin-like growth factor-1 (Igf1). Hypertension drove selective in situ proliferation and transcriptional activation of some cardiac RM states, directly correlating with increased cardiomyocyte growth. During hypertension, inducible ablation of RMs or selective deletion of RM-derived Igf1 prevented adaptive cardiomyocyte growth, and cardiac mass failed to increase, which led to cardiac dysfunction. Single-cell transcriptomics identified a conserved IGF1-expressing macrophage subpopulation in human cardiomyopathy. Here we defined the absolute requirement of RM-produced IGF-1 in cardiac adaptation to hypertension.

Indexed as

Adaptation, PhysiologicalAnimalsHeart FailureHumansHypertensionInfantInsulin-Like Growth Factor IMacrophagesMaleMiceMiddle AgedMyocardiumVentricular RemodelingInsulin-Like Growth Factor Icardiaccardiomyocyte hypertrophyfate mappingheart failurehypertensionIGF-1macrophagesorgan growthresident macrophagesscRNA-seq

Identifiers

PMID34363749
PMCPMC12797153
OpenAlexW3187586511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.