Evidence map›Paper›PMID 34363586›Full record

ArticleEndocrine2021

Incidence of De Quervain's thyroiditis during the COVID-19 pandemic in an area heavily affected by Sars-CoV-2 infection.

Ilenia Pirola, Elena Gandossi, Mario Rotondi, Fiorella Marini, Alessandra Cristiano, Luca Chiovato, Maurizio Castellano, Alberto Ferlin, Carlo Cappelli

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. COVID-19 pandemic and thyroid diseases.Frontiers in endocrinology · 2026
    Article
  4. Subacute Thyroiditis-Is it Really Linked to Viral Infection?The Journal of clinical endocrinology and metabolism · 2025
    Article
  5. Review
  6. Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Subacute thyroiditis during the COVID-19 pandemic: a prospective study.Journal of endocrinological investigation · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ilenia PirolaDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy.
Elena GandossiDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy.
Mario RotondiUnit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Laboratory for Endocrine Disruptors, University of Pavia, Pavia, Italy.
Fiorella MariniDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy.
Alessandra CristianoDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy.
Luca ChiovatoUnit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Laboratory for Endocrine Disruptors, University of Pavia, Pavia, Italy.
Maurizio CastellanoDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy.
Alberto FerlinDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy.
Carlo CappelliDepartment of Clinical and Experimental Sciences, SSD Medicina ad Indirizzo Endocrino-Metabolico, ASST Spedali Civili di Brescia, University of Brescia, 25123, Brescia, Italy. carlo.cappelli@unibs.it.ORCID 0000-0003-4317-1232
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the possible association between Covid-19 infection and subacute thyroiditis.

methodsWe reviewed the medical and imaging records of patients referred to our Department's outpatient setting dedicated to 'thyroid emergency' (records with a 'bollino verde'-green sticker, classifed as urgent) from April 2020 to October 2020. This outpatient clinic is devoted to patients requiring evaluation for severe hypothyroidism, thyrotoxicosis and neck discomfort or pain. All patients with a newly-diagnosed subacute thyroiditis were selected. The data of all patients receiving a diagnosis of subacute thyroiditis was collected retrospectively, taking into account the same period of time (April-October) and starting from 2016.

resultsDuring the COVID-19 outbreak in our region (April 2020 to October 2020) 396 patients attended the outpatient emergency clinic. Among them, 10 (2.5%) patients received a diagnosis of subacute thyroiditis. In a single patient, a 44-year-old man, a COVID-19 pulmonary infection had been diagnosed 7 weeks before the diagnosis of subacute thyroiditis. All of the remaining patients were and remain COVID-19 free as confirmed by telephone interview. The percentage of patients who received a diagnosis of subacute thyroiditis in the same period starting from 2016 was very similar (2.9%, 2.9%, 2.6% and 3.0% in 2016, 2017, 2018 and 2019, respectively).

conclusionsOur data do not show an increase in the incidence of subacute thyroiditis in the Brescia area, a region with the highest prevalence of COVID-19 in Italy during the period of the pandemic outbreak.

Indexed as

COVID-19ThyroiditisThyroiditis, SubacuteAdultHumansIncidenceMalePandemicsRetrospective StudiesSARS-CoV-2COVID-19De QuervainSubacute thyroiditisThyrotoxicosis

Identifiers

PMID34363586
PMCPMC8349140
OpenAlexW3191261726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.