ArticleClinical rheumatology2022
Serum sodium level associated with coronary artery lesions in patients with Kawasaki disease.
Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Age-specific Association of Serum Albumin with Immunoglobulin Resistance and Coronary Artery Involvement in Kawasaki Disease.Pediatric cardiology · 2026Article
- A risk stratification model for coronary artery lesions in Kawasaki disease: focus on subgroup-specific utility.Frontiers in cardiovascular medicine · 2025Article
- Basic Investigations in Pediatric Rheumatology.Indian journal of pediatrics · 2024Review
- [Predictive indicators and risk model construction for coronary artery lesions in Kawasaki disease children over 5 years old].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease.Frontiers in cardiovascular medicine · 2024Article
- Prognostic nutritional index value in the prognosis of Kawasaki disease with coronary artery lesions.Frontiers in nutrition · 2023Article
- Serum alanine aminotransferase level and intravenous immunoglobulin resistance in patients with kawasaki disease.Clinical rheumatology · 2022Article
- [Association between duration of fever before treatment and intravenous immunoglobulin resistance in Kawasaki disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Risk factors and coronary artery outcomes of coronary artery aneurysms differing in size and emergence time in children with Kawasaki disease.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
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Abstract
INTRODUCTION/
objectivesHyponatremia is a potential risk factor for the development of coronary artery lesions (CALs) identified after acute Kawasaki disease (KD). However, the serum sodium distribution corresponding to the reference intervals differs between infants (< 1 year of age) and older children. We hypothesized the association of serum sodium level with CAL complications differs between infants and older patients with KD.
methodsWe analyzed 21,610 population-based patients who developed KD throughout Japan during 2013-2014. We performed multivariable logistic regression analyses to evaluate the association between serum sodium and CAL complications. Additionally, we stratified the serum sodium distribution associated with CAL complications by infants and older patients.
resultsCALs were identified in 158 (3.6%) infants and 302 (1.8%) older patients. Infants were more likely to develop CALs when within the normal sodium range compared with older patients (75% vs. 29%), whereas most older patients developed CALs with a sodium level lower than the reference interval. Serum sodium ≤ 130 mEq/L indicated significantly higher risk for development of CALs in both groups (adjusted odds ratio [95% confidence intervals] = 3.21 [1.65-6.25] in infants and 1.74 [1.18-2.57] in older patients).
conclusionsSerum sodium distribution associated with CAL complications differed greatly between infants and older patients. Older patients developed CALs with sodium levels lower than the reference interval; however, among infants, hyponatremia was not necessarily a risk factor for developing coronary artery lesion. When considering risk assessments for CALs using serum sodium levels, infants with KD should be distinguished from older patients. Key Points • Hyponatremia is a potential risk factor for the development of coronary artery lesions (CALs) among patients with Kawasaki disease. • However, the serum sodium distribution corresponding to the reference intervals differs between infants (< 1 year of age) and older children. • Most infants developed CALs within the normal sodium range, whereas older patients developed at a range lower than the reference interval. • These findings highlight that when considering risk assessments for CALs using serum sodium levels, infants should be distinguished from older patients.
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