Evidence map›Paper›PMID 34363488›Full record

ArticleSocial psychiatry and psychiatric epidemiology2022

Psychological distress as a risk factor for all-cause, chronic disease- and suicide-specific mortality: a prospective analysis using data from the National Health Interview Survey.

Meghan Hockey, Tetyana Rocks, Anu Ruusunen, Felice N Jacka, Wentao Huang, Bing Liao, Dagfinn Aune, Yafeng Wang, Jing Nie, Adrienne O'Neil

Open access · bronzeAbstract read
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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  12. Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study.Autism : the international journal of research and practice · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 6 countries.

Meghan HockeyIMPACT (The Institute for Mental and Physical Health and Clinical Translation), The Food and Mood Centre, Deakin University, Geelong, Australia.
Tetyana RocksIMPACT (The Institute for Mental and Physical Health and Clinical Translation), The Food and Mood Centre, Deakin University, Geelong, Australia.
Anu RuusunenIMPACT (The Institute for Mental and Physical Health and Clinical Translation), The Food and Mood Centre, Deakin University, Geelong, Australia.
Felice N JackaIMPACT (The Institute for Mental and Physical Health and Clinical Translation), The Food and Mood Centre, Deakin University, Geelong, Australia.
Wentao HuangSchool of Nursing, Guangdong Pharmaceutical University, Haizhu District, Guangzhou, China.
Bing LiaoSchool of Nursing, Guangdong Pharmaceutical University, Haizhu District, Guangzhou, China.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Yafeng WangDepartment of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China.
Jing Nie *Department of Sociology, Institute for Empirical Social Science Research, School of Humanities and Social Sciences, Xi'an Jiaotong University, 28 Xianning West Rd, Xi'an, 710049, Shaanxi, China. njamm.5818@stu.xjtu.edu.cn.ORCID http://orcid.org/0000-0003-4286-0212
Adrienne O'Neil *IMPACT (The Institute for Mental and Physical Health and Clinical Translation), The Food and Mood Centre, Deakin University, Geelong, Australia.
Deakin University · AUGuangdong Pharmaceutical University · CNOslo University Hospital · NOWuhan University · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe risk psychological distress (PD) confers on mortality due to specific chronic diseases compared to suicide is unclear. Using the National Health Interview Survey (NHIS), we investigated the association between PD levels and risk of all-cause and chronic disease-specific mortality and compared the contribution of chronic disease-related mortality to that of suicide.

methodsData from 195, 531 adults, who participated in the NHIS between 1997 and 2004, were linked to the National Death Index records through to 2006. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) across four levels of PD, measured using the Kessler-6 scale. Outcomes included all-cause mortality, and mortality due to all CVDs and subtypes, all cancers and subtypes, diabetes mellitus, alcoholic liver disease and suicide.

resultsDuring a mean follow-up time of 5.9 years, 7665 deaths occurred. We found a dose-response association between levels of PD and all-cause mortality, with the adjusted HRs (95% CI) elevated for all levels of PD, when compared to asymptomatic levels: subclinical 1.10 (1.03-1.16), symptomatic 1.36 (1.26-1.46) and highly symptomatic 1.57 (1.37-1.81). A similar association was found for all CVDs and certain CVD subtypes, but not for cancers, cerebrovascular diseases diabetes mellitus. Excess mortality attributable to suicide and alcoholic liver disease was evident among those with levels of PD only.

conclusionPD symptoms, of all levels, were associated with an increased risk of all-cause and CVD-specific mortality while higher PD only was associated with suicide. These findings emphasise the need for lifestyle interventions targeted towards improving physical health disparities among those with PD.

Indexed as

Cardiovascular DiseasesPsychological DistressSuicideAdultChronic DiseaseHumansProportional Hazards ModelsRisk FactorsCancerCardiovascular diseaseMortalityNational Health Interview SurveyPsychological distressSuicide

Identifiers

PMID34363488
PMCPMC8346782
OpenAlexW3192107812

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.