Evidence map›Paper›PMID 34363352›Full record

ArticleChemistryOpen2021

Distinguishable Targeting of Non-Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration.

Ting Liu, Xin Huang, Lingyun Zhao, Zhongqing Xiao, Zengbei Li, Yi Xin, Shanshan Yang, Di Guo, Wenfei Zhao, Yang Mi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ting LiuDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Xin HuangSchool of Textiles, Zhongyuan University of Technology, No. 41 Zhongyuan Road (M), Zhengzhou, 450007, China.
Lingyun ZhaoDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Zhongqing XiaoDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Zengbei LiSchool of Textiles, Zhongyuan University of Technology, No. 41 Zhongyuan Road (M), Zhengzhou, 450007, China.
Yi XinIntensive Care Unit, Zhengzhou Orthopedics Hospital, No. 56 Longhai Road, Zhengzhou, 450052, China.
Shanshan YangDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Di GuoDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Wenfei ZhaoDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Yang MiHenan Key Laboratory for Helicobacter pylori & Microbiota and GI Cancer, Marshall Medical Research Centre, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.
Hongyun LiDepartment of Respiratory and Critical Care Medicine, The Fifth Affiliation Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou, 450052, China.ORCID 0000-0001-5091-9064
Fifth Affiliated Hospital of Zhengzhou University · CNZhongyuan University of Technology · CNZhengzhou City Hospital · CN

Funding

Henan Province Science and technology 212102310197National Natural Science Foundation of China 21807121
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non-selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor site through their active or passive targeting mechanisms, thereby reducing the toxicity of the drugs in various ways. In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine-caged platinum nanoclusters (Pt NCs-NH

Indexed as

Antineoplastic AgentsApoptosisCarcinoma, Non-Small-Cell LungCell Line, TumorCell MovementCell ProliferationHumansHyaluronan ReceptorsHyaluronic AcidLung NeoplasmsMetal NanoparticlesPlatinumAntineoplastic AgentsCD44 protein, humanHyaluronan ReceptorsHyaluronic AcidPlatinumCD44hyaluronic acidInhibitory invasion and migrationplatinum nanoclusterstargeting bio-imaging

Identifiers

PMID34363352
PMCPMC8409085
OpenAlexW3189521894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.