ArticleJournal of cachexia, sarcopenia and muscle2021
Muscle strength is associated with COVID-19 hospitalization in adults 50 years of age or older.
Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06691490 (Functional MRI Protocols for Studying the Neural Correlates of Effort Perception and the Effects of Targeted rTMS Protocols on Perceived Effort and Effort-based Decision-making), which is not on this map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional MRI Protocols for Studying the Neural Correlates of Effort Perception and the Effects of Targeted rTMS Protocols on Perceived Effort and Effort-based Decision-making
Who cites it
43 citing papers in PubMed.
- Exercise-Based Rehabilitation in Severe COVID-19 Survivors with Long COVID: A Randomized Controlled Pilot Study.Medical sciences (Basel, Switzerland) · 2026Trial
- Trial
- Article
- Effects of Supervised Physiotherapy-Based Exercise on Ovarian Reserve and Spontaneous Pregnancy in Women with Diminished Ovarian Reserve: A Controlled Pilot Study.Life (Basel, Switzerland) · 2026Article
- Musculoskeletal Sequelae of Post-COVID-19 Syndrome: A Systematic Review.Diseases (Basel, Switzerland) · 2025Review
- Article
- Function and activity capacity at 1 year after the admission to intensive care unit for COVID-19.Clinical rehabilitation · 2024Observational
- The Impact of COVID-19 on Functional Capacity and Pulmonary Outcomes in the Hail Region: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- [Factors for spirometric impairment in survivors of severe coronavirus-19 disease].Revista medica del Instituto Mexicano del Seguro Social · 2024Observational
- Low handgrip strength is associated with worse functional outcomes in long COVID.Scientific reports · 2024Article
- Physical fitness level and the risk of severe COVID-19: A systematic review.Sports medicine and health science · 2023Review
- Functional status and quality of life in post-COVID-19 patients two to three weeks after hospitalization: A cross-sectional study.Health science reports · 2023Article
- The Effects of a Pulmonary Rehabilitation Program in Severe and Critical COVID-19 Disease: A Prospective Observational Study.Journal of clinical practice and research · 2023Article
- Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients.Nutrients · 2023Article
- The Effects of Yoga Exercise on Blood Pressure and Hand Grip Strength in Chronic Stroke Patients: A Pilot Controlled Study.International journal of environmental research and public health · 2023Article
- COVID-19 and sarcopenia-related traits: a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Factors associated with mortality in hospitalised, non-severe, older COVID-19 patients - the role of sarcopenia and frailty assessment.BMC geriatrics · 2022Observational
- Furnishing the cachexia landscape: A year of research in JCSM.Journal of cachexia, sarcopenia and muscle · 2022Article
- Observational
- Body Weight May Have a Role on Neuropathy and Mobility after Moderate to Severe COVID-19: An Exploratory Study.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundWeak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization.
methodsData from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity.
resultsThe study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results.
conclusionsMuscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
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