ArticleEnvironmental science and pollution research international2022
Increased serum levels of cadmium are associated with an elevated risk of cardiovascular disease in adults.
Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Toxic heavy metal exposure and heart health: a systematic review and meta-analysis of 324,331 patients.BMC cardiovascular disorders · 2025Pooled it
- Association between urinary heavy metal(loid)s exposure and dyslipidemia in children from e-waste dismantling areas.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Environmental Toxic Metals and Metalloids Exposure and Cardiovascular Health: Current Evidence from Oxidative Stress and Inflammatory Biomarkers as Indicators of Subclinical Cardiovascular Effects.Antioxidants (Basel, Switzerland) · 2026Review
- Association Between Metal Mixtures and C-Reactive Protein Levels: A Study Based on Occupational Populations in China.Biological trace element research · 2026Article
- Association between heavy metal exposure and high-sensitivity C-reactive protein in the elderly: Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2017.Annals of occupational and environmental medicine · 2026Article
- Investigating the Interplay of Toxic Metals and Essential Elements in Cardiovascular Disease.Journal of xenobiotics · 2025Article
- Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health.Biomedicines · 2025Review
- Environmental Impacts on Cardiovascular Health and Biology: An Overview.Circulation research · 2024Review
- Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses.Frontiers in public health · 2024Article
- Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009-2018).Frontiers in cardiovascular medicine · 2024Article
- Blood Cadmium and Abdominal Aortic Calcification in Population with Different Weight Statuses: a Population-Based Study.Journal of cardiovascular translational research · 2023Article
- Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients.BMC cardiovascular disorders · 2023Article
- Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2023Article
- Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke.Nutrients · 2023Article
- Association of blood cadmium with all-cause and cause-specific mortality in patients with hypertension.Frontiers in public health · 2023Article
- Threonine Facilitates Cd Excretion by Increasing the Abundance of GutMolecules (Basel, Switzerland) · 2022Article
- Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland.International journal of environmental research and public health · 2022Article
- An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders.PloS one · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies have determined the effects of exposure to certain heavy metals on cardiovascular disease (CVD); however, the association between cadmium exposure and CVD in adults remains unclear. The relationship between serum levels of cadmium and the risk of CVD was studied by analyzing available data from 38,223 different participants of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. After adjusting for all covariates, we found that higher serum cadmium concentrations were positively related to both the overall risk of CVD (odds ratio (OR): 1.45; 95% confidence interval (CI): 1.22, 1.72; p for trend <0.001) and the risks of its subtypes, including congestive heart failure, coronary heart disease, heart attack, and stroke. Elevated cadmium levels were associated with increased levels of lipids and inflammatory factors, including blood triglycerides, total cholesterol, white blood cells (WBCs), and C-reactive protein (CRP). Our study provided epidemiological evidence that cadmium may increase the risk of CVD by elevating blood lipids and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.