Evidence map›Paper›PMID 34363135›Full record

ArticleEuropean radiology2022

"Million dollar nerve" magnetic resonance neurography: first normal and pathological findings.

Jonadab Dos Santos Silva, Larissa Fidalgo Pereira de Barros, Renan de Freitas Souza, Silvana Machado Mendonça, Flávia Martins Costa, José Alberto Landeiro, Fernanda Cristina Rueda Lopes, Marcus André Acioly

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Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Current Surgical Trends in Carpal Tunnel Syndrome.Archives of plastic surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jonadab Dos Santos SilvaDivision of Neurosurgery, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Larissa Fidalgo Pereira de BarrosDivision of Neurosurgery, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Renan de Freitas SouzaDivision of Neurosurgery, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Silvana Machado MendonçaDivision of Radiology, DASA, Rio de Janeiro, Brazil.
Flávia Martins CostaDivision of Radiology, DASA, Rio de Janeiro, Brazil.
José Alberto LandeiroDivision of Neurosurgery, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Fernanda Cristina Rueda LopesDivision of Radiology, DASA, Rio de Janeiro, Brazil.
Marcus André AciolyDivision of Neurosurgery, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil. marcusacioly@yahoo.com.br.
Universidade Federal Fluminense · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate prospectively the feasibility of magnetic resonance neurography (MRN) in identifying the anatomical characteristics of thenar muscular branch (TMB) of the median nerve, also known as the "million dollar nerve," in patients and controls.

methodsThirteen patients affected by carpal tunnel syndrome (CTS) and four healthy controls had their hands scanned on a 3-T MR imaging scanner for TMB visualization. Median nerve anatomical variations were classified into four groups according to Poisel's classification system modified by Lanz. TMB signal intensity and diameter were assessed for the diagnosis of neuropathy.

resultsTMB was successfully identified in all patients and subjects by using MRN. The most suitable pulse sequences to identify and measure nerve diameter were 3D DW-PSIF and T2-FS-TSE. The axial oblique and sagittal oblique planes are complementary in demonstrating its entire course. TMB had mostly an extraligamentous course with radial side origin (93.8%, each). All patients experienced increased T2 signal intensity (p < 0.001) and thickened nerves. Mean TMB diameters were 1.27 ± 0.21 mm (range, 1.02-1.74 mm) and 0.87 ± 0.16 mm (0.73-1.08 mm) (p = 0.008) in the patient and control groups, respectively.

conclusionMRN is a reliable imaging technique for identification and anatomical characterization of TMB in patients affected by CTS. This innovative imaging workup may therefore be included in the preoperative evaluation of patients scheduled for carpal tunnel release, especially in CTS with TMB involvement or even in isolated TMB neuropathy. KEY POINTS: • Magnetic resonance neurography allows precise visualization of the thenar muscular branch of the median nerve. • Thenar muscular branch anatomical variations can be correctly identified. • Preoperative scanning can contribute to reducing the risk of iatrogenic injuries during carpal tunnel release, especially in carpal tunnel syndrome with thenar muscular branch involvement or even in isolated thenar muscular branch neuropathy.

Indexed as

Carpal Tunnel SyndromeMedian NerveHandHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyCarpal tunnel syndromeMagnetic resonance imagingMedian nervePeripheral nervous system diseases

Identifiers

PMID34363135
OpenAlexW3191040810

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.